Drugs online research references
Acta Endocrinol Suppl (Copenh). 1980;239:23-5.
Effect of glipizide on muscle metabolism in vitro.
Bloch K, Daturi S, Tommasini R.
This paper contains the results of further investigation on the possible extrapancreatic activity of glipizide. An in vitro method, using isolated rat diaphragm was selected. Muscle uptake of C14 glucose and output of labelled CO2, were measured. Insulin was used as the reference substance. The results of our experiments indicate that there is a qualitative difference in the effects of the two experimental situations. However, from these findings it may be assumed that glipizide facilitates the uptake and metabolism of glucose in muscle, thus demonstrating an extrapancreatic effect, which contributes to the hypoglycemic activity of the drug.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7001841&dopt=Abstract
Acta Endocrinol Suppl (Copenh). 1980;239:37-41.
Effects of glipizide on the insulin production by isolated mouse pancreatic islets.
Andersson A, Borg LA.
Glipizide was found to stimulate the insulin release from isolated mouse pancreatic islets incubated at 5.5 mM glucose. The rate of insulin biosynthesis under similar conditions was, however, markedly depressed except at the lowest glipizide concentration tested (5 ng/ml), where the drug stimulated insulin secretion but was without effect on the biosynthetic rate. The inhibition of insulin biosynthesis was also observed in experiments with islets maintained in tissue culture, despite the fact that insulin accumulation in the culture medium was increased throughout the culture period. The present data suggest that glipizide has a transient beta-cytotropic effect, which could suggest that extra-pancreatic factors may be involved in the long-term therapeutic action of the drug.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7001842&dopt=Abstract
Acta Endocrinol Suppl (Copenh). 1980;239:6-8.
Acute effects of acetylsalicylic acid on blood glucose and insulin in non-insulin dependent diabetes.
Tornvall G, Allgen LG.
Two groups of diabetic patients--one treated with diet and glipizide and the other with diet alone--volunteered in the study. After a standard meal blood glucose and insulin were followed for four hours during two separate days. On the first day the patients received their ordinary treatment, whereas on the second 1 g of acetylsalicylic acid was added before the test meal. In both groups an enhanced insulin mobilization was observed, when acetylsalicylic acid has been added. A decrease of the blood sugar level was recorded as well. The latter was however less pronounced in the group of subjects receiving only diet.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7001843&dopt=Abstract
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