Drugs online research references
Diabetes Care. 1982 Nov-Dec;5(6):592-9.
Glycosylated hemoglobin and fasting plasma glucose in the assessment of outpatient glycemic control in NIDDM.
Pecoraro RE, Chen MS, Porte D Jr.
Interpreting measurements of fasting plasma glucose (FPG) and glycosylated hemoglobin (GHb) is subject to inherent limitations. The time course of change in GHb cannot be reliably specified in the individual patient, nor do single measurements of GHb convey any information regarding recent change or stability in glycemic control. To evaluate whether the clinical utility of these measurements may be extended, sequential measurements of FPG and GHb were examined from 16 outpatients with NIDDM followed over periods of 12 successive weeks or longer, including intervals following cessation of prior therapy or initiation of new hypoglycemic therapy with glipizide. In some individuals as well as groups of patients, changes in GHb followed patterns previously described by mean changes among groups of patients. Differing from those patterns, however, other individuals demonstrated prompt improvement in GHb following substantial improvement in FPG, confirming that patterns of change described from group means do not apply to all circumstances of changing glycemic control, though they may represent the most common. By using measurements of both FPG and GHb obtained on a single occasion to calculate a third parameter, called the glycosylated hemoglobin index (GHb-1), accurate information could be obtained regarding changes in glycemic control which occurred over intervals of 1-4 wk prior to the measurements. By this approach the utility of GHb measurements in the management of outpatients with NIDDM may be extended beyond retrospective description of the "average" prior metabolic control to include assessment of recent changes in glycemia, either deterioration or improvement.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6927729&dopt=Abstract
Acta Endocrinol Suppl (Copenh). 1980;239:33-6.
The effect of glipizide treatment on the morphology of retinal capillaries from mice with the obese-hyperglycaemic syndrome.
Agren A, Rehn G, Naeser P.
Glipizide dissolved in saline was given daily as a single subcutaneous injection of 20 microgram to mice with the obese-hyperglycaemic syndrome during the first month of the study. During the following three months meglumin-glipizide was used and the animals were killed after this period. Obese-hyperglycaemic control mice were given daily injections of saline. Lean untreated mice were also used as controls. No significant differences were seen between the body weights of the glipizide treated and the control mice. The results of the blood glucose estimations showed significantly lower values in the glipizide treated animals. There were no change of body weight and blood glucose concentration of the lean mice. The serum insulin levels were not changed. The ratio between endothelial cells and intramural pericytes were significantly lower in the glipizide-treated mice. It is suggested that the techniques used in these experiments may contribute to the study of early morphologic and metabolic changes in the retinal capillaries and the effect of drug treatment.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6933820&dopt=Abstract
Acta Endocrinol Suppl (Copenh). 1980;239:9-10.
Kinetic interaction of glipizide and indoprofen in healthy volunteers.
Melander A, Wahlin-Boll E.
There is accumulating evidence that salicylate and glipizide may exert a clinically relevant interaction. Therefore, it was of interest to examine the possible interactions of glipizide and antirheumatics of non-salicylate character, e.g., phenyl propionic acid derivatives. The present report deals with the possible interaction between glipizide and indoprofen, a novel and potent antirheumatic agent. The subjects studied were 6 healthy volunteers, who took indoprofen 200 mg t.i.d. for 7 days and a single 5 mg dose of glipizide before and during indoprofen medication. Series of blood samples were obtained for measurements of indoprofen, glipizide, and glucose concentrations in blood. In addition, urine concentrations of indoprofen were determined. The concentrations of glipizide and indoprofen were measured by high-pressure liquid chromatography, and that of glucose ezymatically. The results indicate that chronic indoprofen administration may reduce glipizide concentrations in plasma, but this reduction need not lead to a major influence on the blood glucose response to glipizide.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6933822&dopt=Abstract
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