Drugs online research references
J Chromatogr. 1987 Oct 30;421(2):319-26.
High-performance liquid chromatographic determination of glipizide in human plasma and urine.
Emilsson H.
Department of Pharmacy, Karolinska Institute, Huddinge Hospital, Sweden.
A sensitive and selective high-performance liquid chromatographic method for determination of intact glipizide in human plasma or urine has been developed. The plasma and urine samples were acid-buffered, before tolbutamide was added as internal standard. The samples were extracted with benzene, and the organic layer was evaporated to dryness. The residue was dissolved in equilibrated mobile phase (acetonitrile-0.01 M phosphate buffer pH 3.5, 35:65), and an aliquot of 20 microliters was chromatographed on a Spherisorb ODS reversed-phase column. Quantitation was achieved by monitoring the ultraviolet absorbance at 275 nm. The response was linear (0-1000 ng/ml) and the detection limit was 5-10 ng/ml in plasma or urine. The within-assay variation was less than or equal to 10%. No interferences from metabolites or endogenous constituents were observed. The utility of the assay was demonstrated by determining glipizide in samples from a diabetic subject receiving a therapeutic dose of 5 mg of the drug.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3429586&dopt=Abstract
Probl Endokrinol (Mosk). 1987 Nov-Dec;33(6):10-3.
[Use of glipizide and evaluation of its effect on microcirculation in patients with diabetes mellitus type 2]
[Article in Russian]
Spesivtseva VG, Golubiatnikova GA, Koroleva TV, Pokryshkin VI, Anisimova VN.
The paper is concerned with the assessment of glipizide action in 32 patients aged 34 to 68 suffering from diabetes mellitus with decompensation of metabolic processes. Good tolerance of the drug, its positive hypoglycemic action enhanced by its combined use with acetylsalicylic acid were noted. No convincing proofs of glipizide influence on microcirculatory indices were obtained. In comparing its hemorheological action with other sulfanilurea drugs of the 2nd generation a similar effect of glipizide with manilin as monotherapy was revealed, on the one hand, and, on the other hand, similar action of glipizide with acetylsalicylic acid and diamicron was noted.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3438260&dopt=Abstract
Diabete Metab. 1986 Feb;12(1):10-5.
The impact of treatment on insulin release and relative peripheral resistance during the oral glucose tolerance test. A study of noninsulin-dependent diabetes mellitus and glucose intolerance.
Cederholm J, Wibell L.
Using 75 g oral glucose tolerance tests (OGTTs), insulin release and relative peripheral resistance were studied in two groups of subjects before and after treatment; ten mostly obese subjects with glucose intolerance (GI), who had improved glucose tolerance after six months of diet and exercise with weight reduction; nine nonobese patients with noninsulin-dependent diabetes mellitus (NIDDM), who received a daily dose of 5 mg glipizide for three months. Total insulin release was measured as the total area under the insulin curve during the OGTT. The insulin response to glucose was expressed as the ratio of the incremental area under the insulin curve to that of the glucose curve above fasting levels (delta AUCI/delta AUCG), during the first 30 minutes and the latter part of the test. The glucose uptake rate (M) was measured as the difference between the glucose load and the increase of glucose in the glucose space after compared to before the OGTT. The relative peripheral resistance (rel-R) against glucose-uptake-promoting factors was expressed as 1/M. The main effects of therapy in the GI-group appeared to be a decrease of the mean rel-R value and a decrease of the mean total insulin release. This implies a mainly peripheral action of therapy at receptor and/or postreceptor levels. The mean [delta AUCI/delta AUCG]0-30 value was unchanged and the mean [delta AUCI/delta AUCG]30-120 value was only slightly increased at follow-up.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3516748&dopt=Abstract
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