Drugs online research references
J Int Med Res. 1989 Sep-Oct;17(5):467-72.
Effects of glipizide on beta-endorphin concentration in the brain of genetically diabetic (db/db) mice.
Belon JP, Orosco M, Henry JC, Jacquot C.
Laboratory of Pharmacology, University of Franche-Comte, Besancon, France.
Sulphonylurea drugs have been shown to augment glucose metabolism by both pancreatic and extrapancreatic actions. The regulation of glucose involves a modification of beta-endorphin secretions via central and peripheral mechanisms. beta-Endorphin participates in the regulation of feeding and is implicated both in obesity and diabetes mellitus. This study shows that glipizide could exert its pharmacological action in genetically diabetic (db/db) mice via beta-endorphin secretions by a central mechanism.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2530122&dopt=Abstract
J Int Med Res. 1989 Nov-Dec;17(6):539-46.
Effects of glipizide on beta-endorphin secretions in response to hyperglycaemia in obese cafeteria rats.
Belon JP, Orosco M, Henry JC, Jacquot C.
Laboratory of Pharmacology, University of Franche-Comte, Besancon, France.
Regulation of blood glucose involves the integration of the central nervous system with both hormonal and neural mechanisms. Considerable evidence suggests that beta-endorphin is involved in the regulation of feeding in experimental animals and man. Previous studies have shown that beta-endorphin plays an important role during hyperglycaemia. Glipizide has been shown to increase glucose metabolism by both pancreatic and extrapancreatic actions. This study indicates that glipizide may exert its pharmacological action in obese cafeteria rats through a modification of beta-endorphin secretions via central and peripheral mechanisms.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2534092&dopt=Abstract
Diabetes Res. 1989 Dec;12(4):193-7.
Effects of first and second generation sulphonylureas on cardiotoxicity of strophanthidin in rabbits.
Ballagi-Pordany G, Koszeghy A, Koltai MZ, Aranyi Z, Pogatsa G.
National Institute of Cardiology, Research Department, Budapest, Hungary.
The effects of the first generation sulphonylurea compound gliclazide and the second generation sulphonylurea compound glipizide on strophanthidin toxicity was investigated in rabbits. The sulphonylurea pretreated animals were intravenously infused with 23 mumol/kg strophanthidin until the appearance of the first ventricular ectopic beat and continued thereafter until the appearance of ventricular fibrillation. The first generation sulphonylurea gliclazide increased, while the second generation sulphonylurea glipizide decreased the strophanthidin toxicity in a dose dependent manner. It was concluded that instead of first generation sulphonylureas, second generation sulphonylureas must be preferred in cardiac glycoside treated diabetics, when sulphonylurea treatment is necessary.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2637095&dopt=Abstract
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