Drugs online research references
Proc Soc Exp Biol Med. 1983 Jul;173(3):367-71.
Effect of AY-25,712 and other lipid-lowering agents on liver catalase and liver carnitine acetyltransferase in rats.
Kallai-Sanfacon MA, Cayen MN, Dubuc J, Greselin E, Dvornik D.
The effect of the hypolipidemic agent AY-25,712 on liver catalase and carnitine acetyltransferase was studied in rats. At 250 mg/kg/day for 2 or 4 weeks, i.e., at least 125 times the minimum effective hypolipidemic dose, AY-25,712 had no effect on liver weight or liver catalase. Liver catalase was elevated after a 2-week treatment with clofibrate (+ 30%), bezafibrate (+71%), and fenofibrate (+77%) at doses of 250 mg/kg/day, and with ciprofibrate (+111%) at 25 mg/kg/day. Gemfibrozil at 250 mg/kg/day for 4 weeks increased catalase by 86%. The relative increase in liver weight induced by these compounds showed a good correlation to increased catalase. Nicotinic acid (250 mg/kg/day for 2 weeks) did not alter liver weight or catalase. Clofibrate increased carnitine acetyltransferase by 176% while AY-25,712 had no effect. The results show that AY-25,712 and nicotinic acid did not induce changes in the livers of rats which are associated with treatment by various other hypolipidemic agents.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6867010&dopt=Abstract
Pharmacol Res. 1994 May-Jun;29(4):345-57.
Comparison of lifibrol to other lipid-regulating agents in experimental animals.
Krause BR, Bousley R, Kieft K, Robertson D, Stanfield R, Urda E, Newton RS.
Department of Atherosclerosis Therapeutics, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105.
In vitro data suggests that lifibrol lowers plasma cholesterol by inhibiting cholesterol synthesis. We report that lifibrol is far less potent in vitro and in vivo than lovastatin for inhibiting 14C-acetate incorporation into sterols. Moreover, several major differences between lifobrol and lovastatin were noted in various animal models. In contrast, lifibrol exhibited several activities in common with gemfibrozil, another phenoxy-acid-type drug. Specifically, in normal rats lifibrol, like gemfibrozil, lowered plasma non-HDL-cholesterol and triglycerides, and increased liver weight and hepatic peroxisomal marker enzyme activities. Lovastatin only lowered plasma triglycerides. In cholesterol-fed rats lifibrol and gemfibrozil lowered non-HDL-cholesterol and elevated HDL-cholesterol while lovastatin was inactive. Finally, lovastatin but not lifibrol exhibited hypocholesterolemic activity in normal guinea pigs and resin-primed dogs. Our interpretation is that these data do not support the notion that lifibrol lowers plasma cholesterol in vivo by inhibiting cholesterol synthesis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7971686&dopt=Abstract
Geriatrics. 1987 Aug;42(8):55-9, 62.
Treating hyperlipidemia, Part III: Drug therapy.
Smith DA, Karmally W, Brown WV.
In elderly patients at increased risk for cardiovascular disease due to lipid abnormalities, numerous medications are available for altering such abnormalities. Most of these drugs have side effects which, in the elderly, may necessitate lower dosing than usual. For persons with severe elevations of triglycerides, nicotinic acid (Niacin) and gemfibrozil (Lopid) may be used. For those who need a reduction in the LDL cholesterol, choices include bile acid-binding resins, nicotinic acid, HMG CoA reductase inhibitors, probucol (Lorelco), and neomycin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3110017&dopt=Abstract
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