Drugs online research references
Am J Physiol. 1975 Mar;228(3):815-20.
ATPase activity of kidney mitochondria stimulated by sodium.
Weiner MW.
ATPase activity of intact mitochondria may be induced by the presence of sodium. Mitochondria obtained from kidney cortex or medulla demonstrate a higher sodium-stimulated ATPase than mitochondria prepared from liver. This difference is not due to a greater capacity of kidney mitochondria for ATP hydrolysis. Sodium-stimulated ATPase activity of mitochondria is not further enhanced by magnesium or potassium, nor is it inhibited by ouabain. Furthermore, the ATPase of submitochondrial particles is not enhanced by the presence of sodium. These results indicate that the ATPase activity of mitochondria which is stimulated by sodium is unrelated to the microsomal Na-K-ATPase. mitochondrial sodium-stimulated ATPase is affected by pH, anionic composition, furosemide, and ethacrynic acid. The demonstration that mitochondrial ATP hydrolysis can be activated by sodium suggests that intracellular sodium may directly influence intracellular energy metabolism.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=234691&dopt=Abstract
J Cardiovasc Pharmacol Ther. 1996 Oct;1(4):271-278.
Effects of Various Modalities of Oral Furosemide Administration in Mild or Severe Congestive Heart Failure.
Cohen N, Dishi V V, Zaidenstein R, Soback S, Weissgarten J, Averbukh Z, Gips M, Blatt A, Berman S, Modai D, Golik A.
Department of Internal Medicine "A&rdquo, Kimron Veterinary Institute, Zerifin, Israel
BACKGROUND: This study evaluated the optimal formulation (tablet vs solution) and frequency (once vs twice daily) of maintenance oral furosemide in compensated congestive heart failure (CHF). METHODS AND RESULTS: Eighteen patients with mild (group 1) and 18 with severe (group 2) CHF were studied. On 2 consecutive days each patient's individual fixed oral furosemide daily dosage was administered in tablet or solution in a crossover design. In an additional study, 14 patients with severe CHF received the daily dosage in tablet or solution form in two divided doses. Pharmacokinetic data were obtained in six randomly allocated patients of each group, during the once daily administration periods of either formulation. Twenty-four-hour urinary sodium and 12-hour volume were significantly greater in group 1 following furosemide solution versus tablets. In group 2, all parameters were comparable in response to single identical doses in tablets or solution, as well as to once versus twice daily administration of either formulation. These results coincided with a higher C(max) and a shorter t(max) following solution. CONCLUSIONS: A once-daily oral furosemide solution is more effective than the same dosage in tablet form in patients with mild, but not those with severe, CHF. In patients with severe CHF, the natriuretic and diuretic effects are similar whether oral furosemide in tablet or solution is administered in a once or twice daily schedule.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10684427&dopt=Abstract [PubMed - as supplied by publisher]
Ter Arkh. 1992;64(1):93-7.
[Pharmacological modifications of radiation methods for studying the kidneys in determining the nature of the stenosis of the pelviureteral segment in patients with nephrolithiasis. Its outpatient diagnosis]
[Article in Russian]
Iudin LA, Reznichenko AA, Uskov IA, Budkevich IuB.
As many as 17 nephrolithiasis and 6 hydronephrosis patients with surgically verified irreversible (n = 13) and reversible (n = 10) stenosis of the pelviureteral segment were examined. To distinguish the character of the stenosis, use was made of excretory urography and dynamic scintigraphy with progesterone, ultrasound, and dynamic scintigraphy with furosemide. In nephrolithiasis patients, dynamic scintigraphy is less informative as compared to other modifications. As compared to hydronephrosis patients, all the modifications indicated are less informative in nephrolithiasis patients in differentiating the character of the stenosis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1523575&dopt=Abstract
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