Drugs online research references
J Investig Allergol Clin Immunol. 1992 Jul-Aug;2(4):196-204.
Bronchial challenge with aspirin lysine in the diagnosis of asthmatics with sensitization to aspirin and its inhibition by aerosolized furosemide.
Croce M, Costa Manso E, Croce J, Gato JJ, Vargas F.
Allergy and Clinical Immunology Service, Clinical Hospital, Faculty of Medicine, University of Sao Paulo, Brazil.
We performed bronchial challenge with ASA lysine in 9 patients with a history of aspirin-induced asthma, 4 asthmatics with no history of hypersensitization to aspirin and 4 control subjects. The test consisted of successive inhalations of increasing concentrations of ASA lysine (11.25, 22.5, 45, 90, 180 and 360 mg/ml) and was interrupted when FEV1 showed a decrease of at least 20%. In order to determine the degree of bronchial hyperreactivity, we first carried out a bronchial challenge with histamine. All patients in the group sensitive to aspirin had a positive reaction to ASA lysine, while this was negative for patients in the two control groups. There was no significant correlation between PC20 to histamine and ASA lysine in any of the groups. On the other hand, 6 patients with sensitivity to ASA repeated the bronchial challenge with ASA lysine after previously inhaling furosemide, and in this second test, none of the 6 had a positive reaction. The variation of ASA lysine PC20 in both tests was positive for these patients (p < 0.001).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1342901&dopt=Abstract
Physiol Behav. 1997 Nov;62(5):1145-54.
Drinking in sodium-depleted rats with bile duct, vena cava or portal vein obstruction.
Lane JR, Purhar KK, Fitts DA.
Department of Psychology, University of Washington, Seattle 98195, USA.
The authors investigated whether a depletion of sodium with furosemide enhanced the water and 0.3 M NaCl intakes of rats with experimental cholestasis, portal hypertension or congestive heart failure. These were induced, respectively, by bile duct ligation (BDL), portal vein constriction or vena cava constriction. BDL alone increased daily saline intake. In BDL rats, but not in sham-ligated controls, experience with a prior depletion of sodium enhanced the 2-h saline intake and the retention of water and sodium after a subsequent depletion. Chronic cava constriction, but not portal constriction, enhanced sodium intake and retention after sodium depletion during a 2-h test and enhanced water intake overnight after the test. The results suggest that the ingestion of sodium by BDL and cava-constricted rats may share a common mechanism.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9333211&dopt=Abstract
Cas Lek Cesk. 1997 Sep 10;136(17):533-8.
[Renal hemodynamics and its regulation in recently diagnosed type 1 diabetes mellitus (insulin-dependent diabetes mellitus). The effect of hyperglycemia]
[Article in Czech]
Pelikanova T, Pinsker P, Smrckova I, Stribrna L, Dryakova M.
Institut klinicke a experimentalni mediciny, Praha.
BACKGROUND: The changes in renal haemodynamics are considered to be one of the pathophysiological mechanisms of the development of diabetic nephropathy. The aim of the study was to evaluate the renal haemodynamics and its regulation in insulin-dependent diabetes mellitus (IDDM) during glycemic clamp-induced eu- and hyperglycaemia (5 and 12 mmol/l), and to test the hormonal vasoactive systems after stimulation with furosemide. METHODS AND RESULTS: Renal haemodynamics using the clearances of inulin and paraaminophippuric acid during eu-hyperglycaemic clamp and furosemide test were performed in 21 short-term IDDM patients without microalbuminuria (DM) and in 18 weight-, age- and sex-matched healthy controls (K). The glomerular filtration rate and effective renal plasma flow were comparable in IDDM and C and were not affected by hyperglycaemia. Compared to C diabetics had lowered fractional excretion of sodium (1.41 +/- 0.68 vs 2.23 +/- 0.67%; p < 0.01), which did not change during hyperglycaemia, and lowered furosemide stimulated natriuresis (1242 +/- 339 vs 1606 +/- 340 mumol/min; p < 0.01). Hyperglycaemia resulted in comparable fall in fractional excretion of potassium in both groups (p < 0.001). Decreased basal (5.77 +/- 3.22 vs 10.9 +/- 3.7 mEU/min; p < 0.05) and furosemide-stimulated (12.0 +/- 1.6 vs 21.3 +/- 2.0 mEU/min; p < 0.01) urinary kallikrein has been found in diabetic compared to control subjects. During clamp-induced euglycaemia, kallikrein excretion was comparable in diabetic and control subjects (10.89 +/- 5.98 vs 10.38 +/- 3.73 mEU/min) and significantly declined during intravenous dextrose-induced hyperglycaemia in diabetics (p < 0.01), while it did not change in controls. There were no differences and no changes in plasma renin activity, plasma and urine aldosterone and cortisol in IDDM and C. CONCLUSIONS: The short-term IDDM without renal haemodynamic alterations is associated with the tendency to sodium retention and decreased basal and furosemide-stimulated kallikrein excretion, which is directly related to the blood glucose level. Acutely-induced hyperglycaemia decreases fractional excretion of potassium, which cannot be explained by the changes of evaluated hormonal systems.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9441014&dopt=Abstract
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