Drugs online research references
Kidney Int. 1975 Dec;8(6):362-7.
Effects of furosemide on low-dose mercuric chloride acute renal failure in the rat.
Ufferman RC, Jaenike JR, Freeman RB, Pabico RC.
The use of potent diuretics in acute renal failure remains controversial. Both beneficial and detrimental effects have been reported. In the present study, the effects of both low and high doses of furosemide administered in the developmental and established stages of mercuric chloride-induced acute renal failure were evaluated. Both low and high doses of furosemide produced a significant diuresis when given early in the course of experimental acute renal failure. Despite this diuresis, furosemide did not modify the development of the acute renal failure. Continued administration of a low dose of furosemide had no effect on renal function; however, prolonged administration of high doses of furosemide resulted in significantly lower creatinine clearances 48 hr after induction of acute renal failure. This detrimental effect was due to sodium depletion by the diuretic since it was prevented by continuous replacement of urinary sodium losses. In the absence of sodium depletion, high doses of furosemide produced a significant diuresis, both in the developmental and established phases of acute renal failure, but it had no effect on the degree of renal functional impairment.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1206852&dopt=Abstract
Ultraschall Med. 1987 Oct;8(5):239-42.
[Stress sonography of the lower urinary tract]
[Article in German]
Weckermann D, Harzmann R.
Urologische Abteilung, Universitatskliniken Tubingen.
Mild caliectasis in patients with occult ureteropelvic obstruction can cause difficulties in the decision on operative or non-operative measures. In such situations diuresis renography, diuretic radionuclide urography and perfusion pressure flow studies (Whitaker test) can be very useful. Furosemide-sonography is a new, non-invasive method demonstrating functional subpelvic obstruction. Standardised conditions before and after application of furosemide are necessary. This new diagnostic method is demonstrated based on a evaluation in 22 patients presenting radiological evidence of minor ureteropelvic obstruction.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3317817&dopt=Abstract
Neurosurgery. 1982 May;10(5):555-62.
Large dose thiopental anesthesia for intracranial aneurysm surgery.
Sokoll MD, Kassell NF, Davies LR.
Twenty patients undergoing intracranial aneurysm clipping were anesthetized with doses of thiopental sufficient to produce electroencephalographic burst suppression, nitrous oxide, oxygen, and morphine sulfate. Diuresis was induced with a combination of furosemide and mannitol. The cardiovascular effects of this anesthetic technique were studied. The central venous, pulmonary artery, pulmonary artery wedge, and systemic arterial blood pressures and the cardiac output were determined. The cardiac index and the systemic and pulmonary vascular resistance were calculated. The systemic blood pressure remained unchanged throughout the procedure except during the period of induced hypotension. The cardiac index decreased on the average from 3.3 during the control period to 2.15 litres/minute/m2 after the induction of anesthesia and diuresis (P less than 0.05). During sodium nitroprusside-induced hypotension, there was a further decrease in the cardiac index to 1.81 litres/minute/m2 (P less than 0.05). Changes in the cardiac index were associated with a significant decrease in the central venous and pulmonary artery wedge pressures from 2.5 to 0.1 and 5.9 to 0.2 torr, respectively) and an increased systemic vascular resistance. Cardiovascular performance recovered quickly after termination of the induced hypotension and remained stable in the postoperative period. This anesthetic technique seems to be useful in the surgical repair of intracranial aneurysms.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7099407&dopt=Abstract
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