Drugs online research references
Acta Anat (Basel). 1987;128(2):147-53.
Morphology of the neural lobe of the hypophysis in rats treated with furosemide. I. Neurosecretory axons.
Vazquez R, Carretero J, Dominguez F, Riesco JM.
The changes found in the neurosecretory axons of the neural lobe of the hypophysis were studied in rats treated with furosemide for three days: over the whole period of treatment, the animals, according to each group, were deprived or not of water. In the animals with free access to water the axons contained neurosecretory granules with scarce content and low electron density; only some of them had vacuoles and autophagic bodies. In the animals deprived of water axon morphology was variable and axons showing vacuoles and autophagic bodies were abundant, as well as those presenting lamellar and dense bodies and also those in which filaments prevailed. The most outstanding modifications in this last group of animals were related to the dehydration and were not found in those animals which were given access to water again and which were in consequence rehydrated.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3564887&dopt=Abstract
Acta Anat (Basel). 1987;128(2):171-6.
Morphology of the neural lobe of the hypophysis in rats treated with furosemide. II. Pituicytes.
Vazquez R, Carretero J, Blanco E, Carvajal JC.
Following three days of furosemide administration, the characteristics of the pituicytes in the neural lobe of the rat hypophysis were studied. The pituicytes of the animals which were treated with furosemide and had access to water during the treatment showed scarce cytoplasm organelles, conferring them with a clear appearance (light pituicytes), and a frequent finding was neurosecretory axons enclosed in their own cytoplasm. In the animals deprived of water during treatment, the pituicytes were dense (dark pituicytes) elongated, with a well-developed Golgi apparatus, numerous profiles of smooth endoplasmic reticulum and frequent annular gap junctions. It is concluded that the dehydration induced by the diuretic agent is the cause of the prevalence of the dark pituicytes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3564891&dopt=Abstract
Acta Physiol Scand. 1981 Feb;111(2):179-83.
Autoradiographic localization of 35-S-furosemide at different stages of its renal excretion.
Odlind B, Dencker L.
The renal localization of 35-S-activity was studied by autoradiography at different times (1/2 min intervals) following the rapid injection of a bolus of 70 micrograms 35-S-furosemide into the renal portal system of hens. After removal, both kidneys were freeze-sectioned, freeze-dried and subjected either to apposition autoradiography according to Ullberg or to microautoradiography. There was extensive labelling over cortical areas of the ipsilateral kidney, in the periphery of lobuli, the site of proximal tubular cells. This labelling was maximal at 1 and insignificant already at 4 min post injection. At this time, however, there was a distinct patchy labelling corresponding to collecting ducts. At 7 min post-injection no specific labelling was found. The findings suggest that furosemide in the peritubular blood is accumulated in proximal tubules, rapidly transferred (tubular secretion) to their lumina and carried distally by the tubular fluid, subsequently resulting in high concentrations of the diuretic in the lumina of collecting ducts. Thus the findings are in keeping with the view that active tubular secretion of furosemide in the hen contributes significantly to a high luminal concentration of the drug in more distal parts of the tubules, the likely site of diuretic action.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7282393&dopt=Abstract
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