Drugs online research references
Zhonghua Jie He He Hu Xi Za Zhi. 1995 Dec;18(6):369-71, 384.
[The effect of furosemide and valium on band 3 protein anion transport function in chronic respiratory failure patients]
[Article in Chinese]
Yang X, Mao B, Qian G.
Respiratory Centre, Xinqiao Hospital, Third Military Medical University, Chongqing.
In order to explore the effect of drugs on band 3 protein anion transport function and its clinical significance, several common drugs such as furosemide, hydrochlorothiazide, etc, were tested. The results demonstrated that furosemide, hydrochlorothiazide and valium could inhibit rapidly and reversibly the anion transport function of band 3 protein and led to HCO-3/Cl- exchange restriction. The mechanism of action of the drugs was thought to be an interaction between drugs and the two sites of band 3 protein anion transport system. The reason that pulmonary encephalopathy was induced by diuretics and sedatives may be related to the inhibition of anion transport by the drugs and reduced CO2 elimination. It was necessary to be careful in using these drugs in patients with impaired lung function, especially the patients of cor pulmonale with type II respiratory failure.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8762500&dopt=Abstract
Acta Paediatr. 1994 Mar;83(3):258-61.
Patent foramen ovale with left to right shunt in bronchopulmonary dysplasia: coincidental or associated complication?
Hascoet JM, Hamon I, Didier F, Maurer P, Vert P.
Service de Neonatologie, Maternite Regionale Universitaire, Nancy, France.
Despite the use of exogenous surfactants, the incidence of bronchopulmonary dysplasia (BPD) has not decreased as much as expected. Of 208 newborns involved in trials with Exosurf at our center, 51 had BPD. Among these newborns, 8 were found retrospectively to have secondary worsening of respiratory distress syndrome after initial improvement with surfactant treatment. Oxygen requirements decreased from 89 +/- 15% to 58 +/- 16% (mean +/- SD), respectively, before and 48 h after surfactant, and then reached a plateau of 34 +/- 10% before dramatic deterioration at 22 +/- 9 days of life. The patients had signs of cardiac failure and increased oxygen requirements of up to 76 +/- 19% within 6 h. A patent foramen ovale (PFO) was demonstrated at echocardiography with a left to right shunt at Doppler. No other cause of worsening was found. Five infants had significant improvement when treated with digoxin and furosemide. This retrospective study raises questions about the relationship between PFO and BPD that should be explored in a prospective study.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8038524&dopt=Abstract
Nephron. 1992;62(3):332-9.
Renal involvement in leptospirosis: a pathophysiologic study.
Magaldi AJ, Yasuda PN, Kudo LH, Seguro AC, Rocha AS.
Laboratorio de Pesquisa Basica da Unidade de Doencas Renais, Faculdade de Medicina, Universidade de Sao Paulo, Brasil.
The kidney involvement in leptospirosis appears to be a special form of acute renal failure due to a higher frequency of polyuric forms and the presence of hypokalemia with an elevated urinary fractional excretion of potassium. Using a clearance technique, we detected higher fractional urinary potassium excretion in leptospirotic guinea pigs (26.5 +/- 4.7%) than in normal animals (14.1 +/- 2.8%, p < 0.05). After blocking distal NaCl reabsorption with furosemide, it was observed that in leptospirotic animals both fractional sodium excretion (40.0 +/- 7.4%) and fractional potassium excretion (136.3 +/- 32.7%) were higher than in normal animals (20.4 +/- 3.8%, p < 0.05, and 43.6 +/- 9.0%, p < 0.05, respectively). Microperfusion studies showed that the normal and leptospirotic medullary thick ascending limb had both identical transepithelial potential difference (+3.7 +/- 0.4 vs. 3.9 +/- 0.2 mV) and relative sodium-to-chloride permeability. The same technique showed that the osmotic water permeability (Posm; 0.9 +/- 0.4 x 10(-5) cm/s.atm) and diffusional permeability (34.7 +/- 6.6 x 10(-5) cm/s) observed in the leptospirotic inner medullary collecting duct (IMCD) in the presence of vasopressin were unchanged, as was also the case for urea permeability (3.74 +/- 0.7 x 10(-5) cm/s). These data show that acute renal failure in leptospirosis is characterized by tubular changes leading to potassium secretion probably due to a decrease in proximal sodium reabsorption. Furthermore, the inability to concentrate urine evidenced by the low P(o)sm present in leptospirotic animals is due, at least in part, to IMCD resistance to vasopressin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1436348&dopt=Abstract
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