Drugs online research references
J Cardiovasc Surg (Torino). 1978 Sep-Oct;19(5):471-9.
The effect of furosemide on renal function in open heart surgery.
Nuutinen LS, Kairaluoma M, Tuononen S, Larmi TK.
The effect of furosemide on renal function in patients undergoing open heart surgery was investigated, using creatinine clearance, urine flow, sodium and potassium excretion as the parameters. The effect of furosemide (2 mg/kg i.v.) on blood flow in arteria renalis and the tissue oxygen tension of the renal cortex and medulla were also investigated experimentally in six dogs. The flow was measured with an electromagnetic flowmeter and the tissue oxygen tension with IBC tissue oxygen electrodes. Prolongation of the perfusion time to more than 60 minutes resulted in a decline of creatinine clearance to appr. 50% of the initial level. Prophylactic furosemide given prior to the perfusion brought down the creatinine clearance to 64% of the initial level. Furosemide, administered either prophylactically just before the cardiopulmonary bypass or after urine flow had declined below 0.5 ml/kg/h, had no effect on the potassium balance in the long perfusion group (over 60 minutes), though it clearly increased the negative potassium balance in the short perfusion group (below 60 minutes). In an experimental work on dogs, furosemide was found to elevate the tissue oxygen tension in the renal cortex and and medulla, and slightly to increase the blood flow in arteria renalis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=711815&dopt=Abstract
J Pediatr. 1980 Apr;96(4):721-6.
Serum salicylate levels and right-to-left ductus shunts in newborn infants with persistent pulmonary hypertension.
Perkin RM, Levin DL, Clark R.
Although a right-to-left shunt via a patent ductus arteriosus is one criterion for the diagnosis of persistent pulmonary hypertension of the newborn infant, it cannot be demonstrated by simultaneous pre- and postductus arteriosus blood oxygen tensions in many infants with the clinical syndrome. In animals, exposure of the fetal ductus arteriosus to salicylates causes contriction and results in pulmonary hypertension. We postulated that maternal ingestion of salicylates and premature closure of the ductus arteriosus may explain why some infants with PPHN do not have right-to-left ductus shunts. Therefore, we studied serum salicylate levels in six groups of infants: I, normal infants' cord blood (0.73 +/- 0.44 mg/dl, N = 20); Ia, normal infants at 24 to 36 hours of age (0.08 +/- 0.1 mg/dl, N = 5): II, other cardiopulmonary diseases with no right-to-left ductus shunt (2.08 +/- 1.74 mg/dl, N = 26); III, other cardiopulmonary diseases and right-to-left ductus shunt (2.34 +/- 1.70 mg/dl, delta Pao2 70 +/- 71 mm Hg, N = 6); IV, PPHN and right-to-left ductus shunt (1.86 +/- 1.51 mg/dl, delta Pao2 39.6 +/- 58.9 mm Hg, N = 5); V, PPHN without right-to-left ductus shunt (7.77 +/- 5.18 mg/dl, delta Pao2 2.2 +/- 1.5 mm Hg, N = 6). Serum salicylate levels were significantly greater (P less than 0.01) in infants with PPHN without right-to-left ductus shunt, indicating that the ductus arteriosus may have been closed prematurely. No other factor, including serum bilirubin, amikacin, ampicillin, or furosemide levels, could be found to account for the difference in serum salicylate levels. Premature closure of the ductus arteriosus secondary to maternal ingestion of salicylates may be one cause of PPHN and may explain the absence of right-to-left ductus shunting in some infants with the clinical syndrome.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7359281&dopt=Abstract
Agents Actions. 1994 Jun;41 Spec No:C47-8.
Effect of loop diuretics on rat peritoneal and human lung mast cells.
Redrup AC, Pearce FL.
Department of Chemistry, University College London, UK.
The effects of furosemide and bumetanide on immunologically stimulated rat peritoneal and human lung mast cells were compared. Furosemide and bumetanide had different modulatory actions on the rat peritoneal mast cell. Furosemide inhibited anti-IgE-induced histamine release. Preincubation of the cells with the drug, prior to anti-IgE stimulation, significantly reduced furosemide's inhibitory effect. In contrast, bumetanide potentiated anti-IgE-induced histamine secretion from the rat peritoneal mast cell. Both diuretics were modest inhibitors of anti-IgE-mediated histamine release from human lung mast cells. For furosemide, inhibition decreased with preincubation, while preincubation increased bumetanide's inhibitory action.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7526657&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics