Drugs online research references
Pol Tyg Lek. 1993 Jan 4-11;48(1-2):6-9.
[Basal and reactive renin and aldosterone secretion in arterial hypertension of insulin dependent diabetics]
[Article in Polish]
Czech A, Taton J, Laz R.
Katedry i Kliniki Chorob Wewnetrznych i Diabetologii AM, Warszawie.
The aim of the study was to assess the significance of the renin-angiotensin-aldosterone system (R-A-A) in the pathogenesis of arterial hypertension in patients with diabetes type I (IDDM). Testing was accomplished in the hospital conditions in a group of 131 patients with long-term IDDM, who beside of diabetes mellitus and its chronic complications did not show any symptoms of additional diseases. The patients were divided in 5 groups (A-E) depending on the type of coexisting late diabetic complications. The control group was consisted of 20 healthy persons matched for sex and age. In each case the following tests were performed: measurement of blood pressure in succumbent position, daily profile of glycemia and glucosuria, Hb A1 level, ophthalmoscopy, functional assessment of kidney and autonomic system status. Tenin activity in plasma (ARO) and plasma aldosterone (ALD) were determined in basal (after 6 h of succumbent position) and after i.v. administration of 40 mg of furosemide and 3 h of standing position (reactive values). In all groups under study the significant decrease of average, basal and reactive ARO was found in comparison with the control group. This abnormality was the most distinct in subjects with diabetic nephropathy. The autonomic neuropathy was abolishing this tendency. The mean concentration ob basal ALD was in all diabetic subgroups similar as in the controls. The mean reactive ALD was however significantly decreased. In diabetes complicated by retinopathy the negative correlation between ARO and systolic, diastolic and mean blood pressure existed. In diabetes complicated by nephropathy the dependence between blood pressure and ARO and ALD was not found.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8361886&dopt=Abstract
Jpn J Pharmacol. 1994 Jun;65(2):167-70.
Protective effects of KW-3902, a novel adenosine A1-receptor antagonist, against gentamicin-induced acute renal failure in rats.
Yao K, Kusaka H, Sato K, Karasawa A.
Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
We investigated the possible renal protective effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), an adenosine A1-receptor antagonist, against gentamicin (GM)-induced acute renal failure (ARF) in rats. ARF was induced by subcutaneous injection of GM at 80 mg/kg/day for 12 days. KW-3902 (0.001-0.1 mg/kg, p.o., twice daily) attenuated the increases of serum creatinine and urea nitrogen and the decrease of creatinine clearance in rats treated with GM. In contrast, furosemide and trichlormethiazide aggravated the GM-induced nephrotoxicity. These results suggest that KW-3902 can ameliorate the GM-induced ARF and that endogenous adenosine may be involved in GM-induced ARF via the adenosine A1-receptor.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7967229&dopt=Abstract
Am J Med Sci. 1982 May-Jun;283(3):119-28.
Natriuretic responses in labile hypertension.
Luft FC, Grim CE, Fineberg NS, Henry DP, Weinberger MH.
To characterize humoral and renal excretory responses following provocative maneuvers in subjects with labile hypertension, we measured plasma renin activity (PRA), plasma aldosterone (PA), plasma norepinephrine (PNe), urinary norepinephrine (UNe), urinary sodium excretion (UNaV), urinary potassium excretion (UKV), and fractional excretion of sodium (FENa) following both volume expansion with a 150 mEq Na diet and intravenous administration of 2L normal saline over four hours, and volume contraction with a 10 mEq Na diet and 120 mg oral furosemide. Results from 37 labile hypertensives were compared to those from the same number of age-, race-, and sex-matched normal subjects or patients with fixed essential hypertension. PRA, PA, PNe, UNe, and UKV responses were no different in the three groups. UNaV and FENa during the saline load was greater in labile hypertensives than in the other groups. While FENa was inversely related to PRA in both normals and fixed hypertensives, no such relationship was found in subjects with labile hypertension. In labile hypertensives, FENa was correlated with PNe concentrations. Furthermore, in these subjects sodium excretion and norepinephrine excretion were associated as well. We suggest that labile hypertensives exhibit exaggerated natriuresis which may be mediated by neurogenic mechanisms.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7044124&dopt=Abstract
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