Drugs online research references
J Vet Pharmacol Ther. 1988 Jun;11(2):121-9.
Effect of diuretics on ketamine and sulfanilate elimination in cats.
Hanna RM, Borchard RE, Schmidt SL.
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520.
Rate constants of elimination were used to evaluate potential effects of diuretic agents on the elimination of ketamine from the blood of cats. Furosemide, mannitol, and aminophylline did not significantly alter the ketamine elimination rate constants, although the diuretics had a tendency to prolong elimination. This tendency of furosemide was further substantiated by observing the effect of furosemide on glomerular filtration. The rate of sulfanilate elimination, used as an indicator of glomerular filtration, was significantly decreased in the cats that were administered furosemide. Possible mechanisms for the influence of furosemide on the renal excretion of ketamine are discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3141631&dopt=Abstract
Miner Electrolyte Metab. 1982;7(5):265-72.
Zinc deficiency and the kidney. II. Response of zinc-deficient rats to three diuretic drugs.
Ross PK, Noordewier B, Hook JB, Bond JT.
Carbonic anhydrase is a zinc metalloenzyme whose activity may be affected by zinc deficiency. This investigation was designed to evaluate the effect of zinc deficiency on the response to three diuretic drugs which vary in their capacity to inhibit carbonic anhydrase: acetazolamide, furosemide and hydrochlorothiazide. The response of the zinc-deficient rats was compared to that of pair-fed and ad libitum zinc-supplemented controls. The pattern of electrolyte excretion by zinc-deficient rats in response to the three diuretics was qualitatively similar to that of the pair-fed and zinc-supplemented rats. When corrected for differences in body weight between the three groups, the natriuretic response to the diuretics in zinc-deficient rats was greater than that of either the pair-fed or zinc-supplemented controls. Although administration of the diuretics increased potassium excretion in all groups, the response of the zinc-deficient rats was attenuated. These differences in the response of zinc-deficient rats to diuretics did not appear to be related to the capacity of these drugs to inhibit carbonic anhydrase.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7169990&dopt=Abstract
Neurosci Lett. 2000 Aug 18;290(1):76-8.
mRNA expression of kidney-specific ClC-K1 chloride channel in single-cell reverse transcription-polymerase chain reaction analysis of outer hair cells of rat cochlea.
Kawasaki E, Hattori N, Miyamoto E, Yamashita T, Inagaki C.
Department of Pharmacology, Kansai Medical University, Fumizono-cho 10-15, Moriguchi-shi, 570-8506, Osaka, Japan.
Outer hair cells (OHCs) of cochlea have been suggested to have Cl(-) channels sensitive to an ototoxic diuretic, furosemide. We therefore examined whether kidney-specific chloride channels (ClC-K1 and ClC-K2) and ClC-5 are also expressed in OHCs of rat cochlea, assuming that these channels might be the targets of oto-nephrotoxic drugs, by single-cell reverse transcription-polymerase chain reaction (RT-PCR) technique. Single-cell RT-PCR revealed the presence of transcripts of ClC-K1 in OHCs which was verified by DNA sequencing, while ClC-K2 and ClC-5 were not detected. The possible roles of ClC-K1 in OHCs are discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10925178&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics