Drugs online research references
J Neurosurg. 1989 May;70(5):785-92.
The effect of furosemide on intracranial pressure and hemorrhage in preterm rabbits.
Lorenzo AV, Greene CS Jr, Hornig GW, Zavala LM, Welch K.
Department of Neurosurgery, Children's Hospital, Boston, Massachusetts.
The hypothesis that intracranial hypotension due to excessive postnatal fluid loss places the premature infant at risk for germinal matrix and intraventricular hemorrhage (GM-IVH) was tested in preterm rabbits delivered at 28 and 29 days of gestation (term 32 days). Furosemide administered to newborn pups induced a diuresis that resulted in a 11% to 22% loss in body weight and a concomitant decline in muscle water (13% to 16%) and sodium (18% to 21%). Paradoxically, no change occurred in the water or electrolyte content of the brain even though cerebrospinal fluid and brain tissue pressure, but not blood pressure, declined. These changes were absent in littermates treated with saline. Microscopic examination of brain sections revealed a greater incidence of intracranial hemorrhage, particularly in the germinal matrix and choroid plexus, in furosemide-treated than in saline-treated preterm rabbit pups. These results are consistent with the hypothesis that intracranial hypotension promotes the incidence of GH-IVH in preterm animals.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2709119&dopt=Abstract
Curr Eye Res. 1989 Jun;8(6):553-6.
Precocious retinal adhesion is affected by furosemide and ouabain.
Frambach DA, Roy CE, Valentine JL, Weiter JJ.
Department of Ophthalmology, University of Southern California, Los Angeles.
A "precocious" adhesive force develops between the neurosensory retina (NSR) and the retinal pigment epithelium (RPE) 15-30 minutes after eyes are removed from day 15 embryonic chickens and incubated at 37 degrees C. Precocious adhesion has been reported to be blocked by exposure to cold but to be unaffected by exposure to furosemide and ouabain. Since RPE transport is thought to play a major role in the adhesion between the RPE and NSR of adult mammals, and since ouabain and furosemide block RPE transport in embryonic chickens, it has been thought that precocious adhesion in embryonic chickens is not a good model for studying adhesion between the RPE and the NSR of adult mammals. We have found, however, that when steps are taken to ensure that ouabain and furosemide reach the transport sites on RPE apical membrane before precocious adhesion develops, that ouabain and furosemide do affect precocious adhesion.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2743794&dopt=Abstract
Farmakol Toksikol. 1989 Mar-Apr;52(2):43-6.
[Furosemide-induced changes in the inhibiting action of urea and lactate dehydrogenase isoenzyme]
[Article in Russian]
Lebedev AA, Novikova RF.
Experiments on rat tissues in vitro showed that the effect of furosemide on the activity of lactate dehydrogenase significantly changes against the background of the action of 2M urea. Furosemide decreases the activity of urea-stable fractions of lactate dehydrogenase in the kidney tissues at concentrations of 10(-6) and 10(-7) M, whereas in the liver and heart tissues this effect occurs at the concentration of 10(-3) M. However the introduction of furosemide in the incubation mixture before the addition of urea eliminates its inhibitory effect on lactate dehydrogenase activity in the kidney and its cortical layer at the concentration of 10(-6) M, in the medulla at 10(-5) M and in the liver and heart tissues only at 10(-3) M.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2744142&dopt=Abstract
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