Drugs online research references
Am J Cardiol. 1998 Jan 1;81(1):87-90.
Effects on left ventricular mass and function of low doses of enalapril for systemic hypertension.
Gonzalez-Juanatey JR, Reino AP, Garcia-Acuna JM, Varela Roman A, Calvo Gomez C, Cabezas-Cerrato J.
Cardiology Department and Hypertension Unit, Complexo Hospitalario Universitario de Santiago de Compostela, Spain.
After 7 years of treatment with 20 mg of enalapril twice daily, regression of the initial left ventricular hypertrophy in a group of 24 patients with essential arterial hypertension was achieved: gradual reduction in the dosage to 10 or 5 mg twice daily caused no worsening of either blood pressure or ventricular structure or function.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9462614&dopt=Abstract
Mol Cell Endocrinol. 1987 Apr;50(3):223-9.
Relationship between renin mRNA and renin secretion in adrenalectomized, salt-depleted, or converting enzyme inhibitor-treated rats.
Ludwig G, Ganten D, Murakami K, Fasching U, Hackenthal E.
Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Relative amounts of renin mRNA were measured by densitometric Northern blot analysis using a 32P-labeled 700 bp mouse submaxillary gland cDNA fragment as hybridization probe. Renin secretion was measured in isolated kidneys taken from pretreated rats. Treatment resulted in a 4.4-, 7- and 12.7-fold increase in total renin mRNA in kidneys of ADX, MK 421 and FUR rats, respectively. Plasma renin levels increased 5-, 9- and 12-fold in ADX, MK 421 and FUR rats, whereas ex vivo secretion rates from the isolated kidney were 4.7-, 0.5- and 4.2-fold, respectively, that of controls. Thus, a close relationship between increases in renin secretion in vivo (reflected by plasma renin concentration) and renin mRNA exists, whereas secretion rates in the isolated perfused kidney ex vivo change in a non-proportional fashion.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3032710&dopt=Abstract
J Hypertens Suppl. 1988 Dec;6(4):S684-6.
Effect of captopril on murine systemic lupus erythematosus disease.
Herlitz H, Svalander C, Tarkowski A, Westberg G.
Department of Nephrology, University of Gothenburg, Sweden.
The MRL/1 and New Zealand black-New Zealand white cross (NZB x W) mice spontaneously develop a disease similar to systemic lupus erythematosus in man. The effect of antihypertensive treatment on MRL/1 and NZB x W mice was studied with respect to survival, blood pressure, proteinuria, haematuria and renal histopathology. The treatment consisted of angiotensin converting enzyme (ACE) inhibitors (captopril and enalapril) and bretylium, a sympathetic blocker. Tail systolic blood pressure was measured with a strain gauge technique. All antihypertensive drugs caused a reduction in blood pressure in both strains. In MRL/1 bretylium and both ACE inhibitors improved renal histopathology, but only captopril prolonged survival, and it decreased proteinuria and haematuria. In NZB x W captopril decreased proteinuria but did not influence survival or renal histopathology. Bretylium was without any effect on these parameters. At the doses used captopril improves survival in MRL/1 mice and decreases proteinuria and haematuria in both MRL/1 and NZB x W mice. Since bretylium and enalapril lack this property despite a similar blood pressure reduction, it seems to be a drug-specific action.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2853767&dopt=Abstract
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