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Eur J Pharmacol. 1996 Sep 26;312(2):235-9.
Antitussive effect of moguisteine on the enhanced coughing associated with enalapril in guinea-pig.

Kamei J, Morita K.

Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

The effect of moguisteine, a novel peripherally acting non-narcotic antitussive drug, on coughs associated with enalapril was examined in guinea-pigs. Chronic treatment with enalapril markedly enhanced the number of capsaicin-induced coughs. Moguisteine dose-dependently suppressed the number of coughs at doses between 3-30 mg/kg p.o., in both vehicle-treated and enalapril-treated animals. There was no significant difference in the antitussive ED50 (95% confidence limit) value of moguisteine between vehicle-treated (16.4 (13.7-19.7) mg/kg) and enalapril-treated (13.7 (3.9-47.6) mg/kg) animals. On the other hand, dihydrocodeine also dose-dependently suppressed the number of coughs in the same dose range as moguisteine in both vehicle-treated and enalapril-treated animals. There was no significant difference in the antitussive ED50 (95% confidence limit) of dihydrocodeine between vehicle-treated (11.7 (4.9-28.3) mg/kg) and enalapril-treated (11.2 (9.4-13.3) mg/kg) animals. Furthermore, the antitussive effect of moguisteine was identical to that of dihydrocodeine in both vehicle-treated and enalapril-treated animals. On the other hand, while chronic co-treatment with moguisteine significantly reduced the number of enhanced coughs associated with enalapril, chronic co-treatment with dihydrocodeine had no significant effect on the number of enhanced coughs associated with enalapril treatment. These results suggest that moguisteine may have a therapeutical benefit in reducing the coughing associated with treatment with inhibitors of angiotensin-converting enzyme.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8894601&dopt=Abstract




Intern Med. 1992 Apr;31(4):441-6.
Nocturnal blood pressure monitored by ambulatory blood pressure measurement in elderly hypertensive patients.

Hayashi T, Goto T, Tateishi T, Yoshimine N, Kuzuya F.

Department of Geriatrics, Nagoya University School of Medicine, Japan.

This study was designed to characterize the nocturnal fall of blood pressure (NFBP) of elderly hypertensive patients (EH), with or without cerebrovascular disease or diabetes mellitus, as measured by automated blood pressure (BP) monitoring. Systolic and diastolic BP and heart rate was measured every 15 minutes in 133 hospitalized patients with nearly similar schedules and diets. The patients were divided into five groups: I, normotensive elderly patients over age 65: II, EH without cardiovascular diseases, controlled without medication: III, EH with cerebral infarction, chronic stage: IV, EH with noninsulin-dependent diabetes mellitus: and V, hypertensives under age 65, without cardiovascular diseases. A significant NFBP was observed in the patients of groups I and V, a significant but smaller NFBP in the hypertensives of groups II and IV, and no NFBP in the patients of group III. Administration of the antihypertensive drugs, enalapril and nifedipine, tended to augment the NFBP. These preliminary observations showed that NFBP did occur in elderly hypertensives but the fall was smaller than that observed in younger hypertensives or elderly normotensives. Although the ambulatory BP measurements were useful in the overall clinical evaluation of elderly patients, NFBP in elderly patients was affected by hypertensive drugs and therefore NFBP should be interpreted with caution.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1633344&dopt=Abstract




Minerva Med. 1998 Apr;89(4):91-7.
[Hospital intensive monitoring of adverse reactions of ACE inhibitors]

[Article in Italian]

Mangrella M, Motola G, Russo F, Mazzeo F, Giassa T, Falcone G, Rossi F, D'Alessio O, Rossi F.

Istituto di Farmacologia e Tossicologia, Facolta di Medicina e Chirurgia, Seconda Universita degli Studi di Napoli.

BACKGROUND AND AIMS: Angiotensin II converting enzyme (ACE) inhibitors represent one of the most important pharmacological instruments for the treatment of arterial hypertension and are currently also used for other cardiovascular indications. The actions of ACE-inhibitors mainly depends on blocking the ACE enzyme in the renin-angiotensin-aldosterone system. However, the ACE enzyme also has a kinase activity. The inhibition of this enzyme may also cause an accumulation of tissue mediators (bradykinin) responsible for a number of adverse reactions. METHODS: An intensive hospital monitoring programme of adverse reactions to drugs, known as MIO[symbol: see text]'96, was carried out by the Centre of Pharmacoepidemiology of the Faculty of Medicine and Surgery at the Second University of Naples during the period 25 March-18 April 1996. The main aims of the programme were to highlight the incidence of adverse reactions to the drugs monitored and the definition of the risk/benefit ratio taking account of the main physiological and pathophysiological variations of patients. This paper reports the results of the programme of adverse effects correlated to the use of ACE-inhibitors. A total of 175 records were compiled for 105 patients receiving antihypertensive treatment with a number of ACE-inhibitors (captopril, enalapril, lisinopril); a very high mean incidence of adverse events was documented (22%) without any severe undesirable effects. RESULTS: The following adverse events were documented (the cumulative incidence is given in brackets): dysgeusia (17%), flush (8%), headache (33%), exanthema (17%), diarrhoea (8%), vertigo (8%), xerostomia (8%). Coughing was not reported in any patient. CONCLUSIONS: Further periods of intensive monitoring will be required to obtain a greater quantity of data from the Intensive Monitoring of adverse events through the MIO[symbol: see text]'97 programme.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9676174&dopt=Abstract












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