Drugs online research references
Farmaco. 1999 Mar 31;54(3):145-8.
Electrochemical behaviour of Venlafaxine and its determination in pharmaceutical products using square wave voltammetry.
Lima JL, Loo DV, Delerue-Matos C, da Silva AS.
CEQUP/Departamento de Quimica-Fisica, Faculdade de Farmacia da Universidade do Porto, Portugal.
An electrochemical method for the determination of Venlafaxine in pharmaceutical formulations recently available on the European market is described. The electrochemical oxidation of Venlafaxine was studied at a HMDE electrode over a wide pH range (1.9-10.0) of buffered aqueous solutions using different potential sweep techniques. The results obtained showed that the best definition of the analytical signals was found in boric acid/potassium tetrahydroxoborate buffer at pH 8.7 using anodic stripping square wave voltammetry. Recovery trials were performed to assess the accuracy of results and these were compared to those provided by a HPLC technique according to the method described in literature and to the features of the pharmaceutical formulations. A relative deviation of < 0.2% was obtained. With the developed methodology, the limit of detection was 0.124 mg/l.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10371026&dopt=Abstract
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Eur J Pharmacol. 1999 May 7;372(1):17-24.
Venlafaxine: acute and chronic effects on 5-hydroxytryptamine levels in rat brain in vivo.
Gur E, Dremencov E, Lerer B, Newman ME.
Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Venlafaxine is a dual serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline uptake inhibitor which has been claimed to have an onset of antidepressant action which is faster than for other comparable drugs. The effects of venlafaxine on brain 5-HT levels in vivo have not yet been examined. Acute administration of venlafaxine to rats by i.p. injection resulted in dose-dependent increases in cortical and hippocampal 5-HT levels, as measured by in vivo microdialysis, over the range 5-20 mg/kg. The effect of venlafaxine (10 mg/kg i.p.) was potentiated by prior administration of pindolol (10 mg/kg s.c.) in hippocampus but not in frontal cortex. Daily administration of venlafaxine (5 mg/kg i.p.) for 4 weeks did not change basal 5-HT levels in either brain area. The effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 0.2 mg/kg s.c.) to reduce 5-HT levels was unaffected by chronic venlafaxine at this dose, indicating that there was no change in sensitivity of presynaptic 5-HT1A autoreceptors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10374710&dopt=Abstract
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Encephale. 1999 Jun;25 Spec No 2:29-31; discussion 32-5.
[Proofs of efficacy]
[Article in French]
Boyer P.
Centre Hospitalier Sainte-Anne, Paris.
Several factors are to be taken account in the assessment of the overall efficacy of a new antidepressant. There are rules governing the diagnostic categories, baseline scores and the conditions for the assessment of their course in the context of both placebo-controlled trials and studies versus reference products. As an illustration, two studies of clomipranine versus specific inhibitors of serotonin reuptake are reviewed. The author analyzes various studies conducted on venlafaxine, a new serotoninergic and noradrenergic product.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10434157&dopt=Abstract
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