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chw.edu.au
Weight-restored patients with anorexia nervosa (AN) respond favorably to the selective serotonin reuptake inhibitor fluoxetine, which justifies association studies of the serotonin transporter gene (SLC6A4, alias SERT) and AN. Case-control studies suggest that the least transcriptionally active allele of the SERT gene promoter polymorphism (5-HTTLPR) has an increased frequency in AN patients. However, this finding was not replicated with 55 trios (AN child+parents) and the transmission disequilibrium test (TDT). To clarify the role of the 5-HTTLPR in susceptibility to AN, we used the TDT and 106 Australian trios to provide 93% power to detect a genotypic relative risk (GRR) of 2.0. Our results were negative for this GRR (McNemar's chi(2)=0.01, df=1, p=0.921, odds ratio 1.0, 95% CI 0.7-1.5). Additionally, we found no association with AN females, AN subtype, age at onset, or minimum BMI. We then performed the first reported investigation of epistasis between the SERT gene and norepinephrine transporter gene (SLC6A2, alias NET) in AN, as an earlier study suggested that atypical AN responds to the dual serotonin-norepinephrine reuptake inhibitor venlafaxine. We observed no epistasis between the 5-HTTLPR and a polymorphism within the NET gene promoter polymorphic region (NETpPR) (chi(2)=0.48, df=1, p=0.490). Although 5-HTTLPR modulates serotonin reuptake by the serotonin transporter, our analyses provide no evidence that susceptibility to AN is modified by 5-HTTLPR alone, nor in concert with as yet undetermined functional effects of the NETpPR polymorphism.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12784104&dopt=Abstract
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poczta.onet.pl
The experiments outlined in this paper examined the effects of the novel antidepressant venlafaxine (VEN) (CAS 9930-78-4) in several behavioural and memory tests in comparison with the classic antidepressant imipramine (IMI) (CAS 113-52-0). The tests were carried out on male Wistar rats of about 200 g. The drugs were administered orally 30 min before the tests during 14 days. The aim of the locomotor activity test was to select the doses without influence on the motility of the animals and active at least in two behavioural tests. Such dose was 20 mg/kg b.w. for both drugs--VEN and IMI. In the immobility test, which reflects antidepressant drug activity, the following differences were found: VEN shortened immobility time (IT) on days 1 and 7 (no activity on day 14), whereas IMI shortened IT on days 7 and 14 and displayed no activity on day 1. In the two-compartment exploratory test both drugs displayed distinct anxiolytic effect on days 1 and 7, yet on day 14 only IMI was still active. In the maze test only VEN shortened food finding time on day 1, on day 7 and on day 14 during chronic treatment. IMI was inactive in the maze test. The authors conclude that the general pattern of VEN activity is similar to that of IMI, but in some tests, especially in the memory test, the new drug is superior to IMI.
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med.ege.edu.tr
The combination of venlafaxine and tramadol was compared with the single use of these agents to investigate the antinociceptive effect on paw withdrawal latency (PWL) to paw pressure in rats with neuropathic pain. Rats were divided into 4 groups: group 1 received saline (0.2 ml i.p.); group 2 received venlafaxine (22 mg/kg i.p.); group 3 received tramadol (20 mg/kg i.p.); and group 4 received venlafaxine + tramadol. No statistically significant changes were observed in the saline and venlafaxine groups with respect to PWL in the lesioned paw. However, tramadol produced a significant antinociceptive effect on the lesioned paw at 30 min compared with the saline and venlafaxine groups. A more potent antinociceptive effect was observed in the tramadol + venlafaxine group, beginning at 60 min and lasting for 1 h. The combination of venlafaxine + tramadol was more effective in increasing the pain threshold in this animal model of neuropathic pain than either of these drugs administered alone. (c) 2003 Prous Science. All rights reserved.
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