Drugs online research references
Tidsskr Nor Laegeforen. 1991 Apr 10;111(9):1102-5.
[The effect of doxazosin on blood pressure, lipids, fibrinogen and plasminogen activator inhibitor. A comparative study among smokers and non-smokers with essential hypertension]
[Article in Norwegian]
Daae LN, Kierulf P, Brusletto B, Westheim A, Holme I, Syvertsen JO.
Klinisk kjemisk avdeling, Ulleval sykehus, Oslo.
Hypertensive cigarette smokers run particularly high risk of coronary heart disease. Doxazosin, which has beneficial effects on haemodynamic factors and lipid metabolism, may be a suitable agent for treating these patients. The effects on blood pressure and metabolic parameters were investigated in a 16-week, open, parallel, comparative study comprising 64 heavy cigarette smokers and 69 non-smokers who received doxazosin after four weeks on placebo. Eight patients (three smokers and five non-smokers) dropped out due to adverse effects. Blood pressure was significantly reduced in both groups, but there was no change in heart rate. Doxazosin induced a decrease in the triglyceride, total cholesterol and LDL-cholesterol levels, and an increase in HDL-cholesterol concentration. Thus, doxazosin has favourable effects on atherogenic factors in smoking hypertensive patients. There was also a significant lowering of plasma fibrinogen levels and plasminogen activator inhibitor (PAI-1) concentration in non-smokers.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1827216&dopt=Abstract
Am J Hypertens. 1999 Nov;12(11 Pt 1):1105-8.
Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats.
Maeso R, Navarro-Cid J, Rodrigo E, Ruilope LM, Lahera V, Cachofeiro V.
Department of Physiology, School of Medicine, Universidad Complutense, Madrid, Spain.
We evaluated the effects of treatment for 12 weeks with 10 mg/kg/day of either losartan or doxazosin on vascular function in senescent spontaneous hypertensive rats (SHR). Both doxazosin and losartan reduced blood pressure, although the former was more effective. In contrast, both drugs reduced relative aortic weight and increased plasma nitrates to a similar extent. Losartan, but not doxazosin, increased the magnitude of the response to acetylcholine (10(-9) to 10(-5) mol/L). Both treatments increased relaxations to sodium nitroprusside (10(-10) to 10(-6) mol/L). These data show that losartan may possess advantages over doxazosin in improving vascular function in senescent SHR. This report emphasizes the importance of angiotensin II in vascular function alterations induced by aging in SHR.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10604487&dopt=Abstract
Aviat Space Environ Med. 1991 Jun;62(6):538-42.
Prolonged photostress macular recovery after reduced blood pressure.
Myhre K, Brinchmann-Hansen O.
Royal Norweigian Air Force Institute of Aviation Medicine, Oslo.
In order to investigate an association between systemic blood pressure and restitution of normal visual function in dim illumination after photostress, macular recovery time and blood pressure were measured in two groups: 1) 90 young and healthy military pilots and applicants for military pilot training; and 2) 10 hypertensive patients before and after 12 weeks of antihypertensive treatment. Young normotensive subjects (20/20 vision) with low diastolic blood pressure performed less well (longer macular recovery time) than those with higher pressure (r = -0.42, p less than or equal to 0.05). Among the hypertensive patients three were given doxazosin, three, prazosin, and four, placebo. The treatment period produced significant fall in blood pressures, a small reduction in intraocular pressure (p less than or equal to 0.03) and a lengthening of initial monocular recovery period (p = 0.04) in addition to reduced monocular (p = 0.015) and binocular (p = 0.022) macular recovery in the remaining part of the 2-min test period. This observation may be important for antihypertensive treated patients whose occupation requires fast visual adjustment to changing stimuli in dim light.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1830470&dopt=Abstract
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