Drugs online research references
Neuropharmacology. 1983 Feb;22(2):249-52.
Cyclobenzaprine effects on locus coeruleus cells in tissue slice.
Lang IM, Barnes CD.
Tissue slices 400 mu thick were taken from the brain stem, at the level of the locus coeruleus, of 150-250 g Sprague-Dawley rats. Microelectrodes were placed in the locus coeruleus under visual control, and a cell whose discharge rate would decrease with microiontophoretic application of norepinephrine or clonidine was sought. Cyclobenzaprine (CBZ) was then introduced into the perfusion medium at a concentration equivalent to 1 mg/kg body weight of the whole animal. Discharge rates before and during CBZ administration were compared. The six cells with initial discharge rates between 2 and 10 Hz decreased firing with CBZ, whereas the four cells with initial rates between 0.5 and 1.5 Hz increased their rates with CBZ.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6835493&dopt=Abstract
J Pharm Sci. 1982 Jun;71(6):656-8.
Determination of cyclobenzaprine in tablets by high-performance liquid chromatography.
Heinitz ML.
A convenient high-performance liquid chromatographic method for the quantitative determination of cyclobenzaprine hydrochloride in tablets is described. Samples were dissolved in 0.05 N sulfuric acid and diluted with methanol. The cyclobenzaprine hydrochloride was chromatographed using an octylsilane column and the eluent acetonitrile-0.6% dibasic potassium phosphate aqueous buffer (pH 3.0) (75:25) at a flow rate of 1.5 ml/min. Naphazoline hydrochloride was used as an internal standard. The UV detector response at 254 nm was linear for cyclobenzaprine hydrochloride in the 0.005-0.03 mg/ml range under conditions of the analysis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7097527&dopt=Abstract
Neurotoxicology. 1981 Dec;2(4):703-9.
Ocular aldehyde dehydrogenase in rodents.
Messiha FS.
The presence of NAD-dependent ocular aldehyde dehydrogenase in rodents is reported. The enzyme is species and strain-dependent. Ocular ALDH possesses a significantly greater specific activity than that of the hepatic tissue of the species studied. d-Amphetamine non-competitively inhibited rat eye ALDH in vitro. Short-term administration of cyclobenzaprine, a tricyclic compound with muscle relaxant property, induced ocular aldehyde dehydrogenase. This is compared with lack of effect of certain CNS-stimulants, ethanol intake and of a monoamine oxidase inhibitor on endogenous ALDH in vivo.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7200582&dopt=Abstract
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