Drugs online research references
Mikrobiyol Bul. 1988;22(3):187-92.
[The in vitro activity of ofloxacin, pefloxacin and ciprofloxacin against various gram negative bacteria isolated from urinary tract infections]
[Article in Turkish]
Tunckanat F, Yulug N.
Hacettepe Universitesi, Tip Fakultesi, Mikrobiyoloji Anabilim Dali Arastirma Gorevlisi.
In this study the in vitro activity of ofloxacin, pefloxacin and ciprofloxacin against various gram negative bacteria isolated from urinary tract infections was examined. Of 80 isolates (24 E. coli, 10 Enterobacter, 10 Klebsiella, 23 Proteus, 10 Pseudomonas, 2 Morganella and 1 Serratia) 49 were from inpatients, and 31 were from outpatients. Ciprofloxacin was the most potent compound and no resistant strain was found against ciprofloxacin, while 1 Enterobacter strain and 1 Pseudomonas strain were found to be resistant to both ofloxacin and pefloxacin. Another Pseudomonas strain was resistant to pefloxacin only. All of the resistant bacteria were from nosocomial infections.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3252111&dopt=Abstract
Pharmacoeconomics. 1997 Apr;11(4):359-66.
Cost-minimisation analysis of sequential treatment with ofloxacin or ciprofloxacin in hospitalised patients.
Salewski E, Bassaris HP, Calangu S, Kitzes R, Kosmidis J, Raz R, Kompan L.
Hoechst AG, Medical Department, Frankfurt am Main, Germany.
This study evaluated the cost of sequential treatment with once-daily ofloxacin or twice-daily ciprofloxacin in 474 hospitalised patients in different countries. The patients were treated intravenously for at least 3 days, then orally for 7 to 10 days or for 3 days beyond the disappearance of infection-related symptoms. The overall clinical cure rate (86.8% with ofloxacin and 89.6% with ciprofloxacin) and the overall bacteriological response rate (89.9 and 89.0%, respectively) were similar, and a cost-minimisation analysis was conducted. The acquisition costs for ofloxacin and ciprofloxacin in Greece, Israel, Slovenia and Turkey were used and converted to Deutschmarks (DM), and the costs of administration were analysed for each hospital. The different cost categories for oral and intravenous (IV) treatment (e.g. antimicrobial acquisition, drug monitoring, drug delivery costs) were used to identify any differences. The total costs per patient varied between the countries involved, but were higher for ciprofloxacin (ofloxacin: DM239 to DM724; ciprofloxacin: DM540 to DM976). In a sensitivity analysis using identical daily acquisition costs for the 2 fluoroquinolones, the total cost of treatment was higher for ciprofloxacin, as a result of the lower cost of administration of ofloxacin in the once-daily regimen. Continuing IV therapy would be approximately 50% more expensive than switching to oral administration; however, whenever possible, both drugs can be switched from IV to oral treatment.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10166410&dopt=Abstract
Antibiot Khimioter. 1992 Jan;37(1):35-9.
[Selective decontamination of the intestine and total gnotobiologic isolation in treatment of mice with acute radiation sickness]
[Article in Russian]
Romanchuk LA, Bush V, Korshunov VM.
Comparative study of ciprofloxacin, pefloxacin and amikacin showed that ciprofloxacin and pefloxacin had a selective action on the intestinal microflora of conventional mice. Amikacin induced inhibition not only of the opportunistic bacteria but also of the representatives of the indigenous microflora. The use of the drugs in combination with total gnotobiological isolation in treatment of experimental radiation sickness provided an increase in survival of the irradiated animals, the more so as ciprofloxacin was used.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1530357&dopt=Abstract
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