Drugs online research references
Chemioterapia. 1988 Jun;7(3):164-8.
Treatment of infections in non-neutropenic patients with cancer, AIDS, or renal transplant using ciprofloxacin.
Maggiolo F, Bianchi W, Ohnmeiss H.
Bayer Italia S.p.A., Medical Department, Milan, Italy.
Infective complications not only remain the major factor in preventing a large proportion of cancer patients from achieving a complete remission, but also greatly influence the outcome of immunosuppressed transplant recipients and are a prominent problem in subjects affected by AIDS. We report the results of 73 patients, 54 males and 19 females with a mean age of 61.4 +/- 15.1 years affected by solid cancer (64 pts), AIDS (6 pts) or with kidney transplant (3 pts), treated with ciprofloxacin 250 mg bid (21 pts) or 500 mg bid (52 pts) for respiratory tract infections (41 cases), urinary tract infections (22), septicemia (5) or other infections (5). The mean course of therapy was 9.6 +/- 5.7 days and led to a complete resolution of symptoms in 66 (90.4%) patients, improvement in 6 (8.2%), while the clinical picture was unaffected in 1 (1.4%). Candida superinfection occurred in one case and only four patients experienced side effects. Ciprofloxacin results to be an effective antibacterial agent in a high risk population.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3048728&dopt=Abstract
Chemioterapia. 1987 Oct;6(5):315-8.
In vitro susceptibility of nosocomial Pseudomonas aeruginosa, enterobacteriaceae, and staphylococci to ciprofloxacin and ten other broad-spectrum antibiotics.
Weinstein RA, Nathan C, Delzell D, Kabins SA.
Department of Medicine, Michael Reese Hospital, Medical Center, Chicago, IL 60616.
We determined microdilution minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) for ciprofloxacin and 10 beta-lactam and aminoglycoside antibiotics against 329 unique nosocomial isolates of Pseudomonas aeruginosa, citrobacter, enterobacter, serratia, and staphylococci. All were susceptible to ciprofloxacin, including 109 aminoglycoside-resistant gram-negative bacilli and 59 oxacillin-resistant staphylococci. Ciprofloxacin was generally 2-4 fold less active against aminoglycoside-resistant isolates than against their aminoglycoside-susceptible counterparts.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3123078&dopt=Abstract
Antimicrob Agents Chemother. 1984 Jul;26(1):94-6.
In vitro activities of norfloxacin and ciprofloxacin against Mycobacterium tuberculosis, M. avium complex, M. chelonei, M. fortuitum, and M. kansasii.
Gay JD, DeYoung DR, Roberts GD.
The activities of ciprofloxacin and norfloxacin against 100 mycobacteria isolates were studied in vitro by the 1% standard proportion method. Ciprofloxacin was more active against M. tuberculosis and M. fortuitum with MICs of 1.0 and 0.25 microgram/ml, respectively, against 90% of isolates; norfloxacin had MICs of 8.0 and 2.0 micrograms/ml, respectively, against 90% of isolates.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6236748&dopt=Abstract
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