Drugs online research references
Chest. 1995 Sep;108(3):712-7.
Chemoprophylaxis of multidrug-resistant tuberculous infection in HIV-uninfected individuals using ciprofloxacin and pyrazinamide. A decision analysis.
Stevens JP, Daniel TM.
Center for International Health, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
STUDY OBJECTIVE: To evaluate the use of ciprofloxacin and pyrazinamide for the prophylaxis of individuals infected with multiply drug-resistant strains of Mycobacterium tuberculosis. DESIGN: Decision analysis, using software (SMLTREE). Probabilities based on published studies, with sensitivity analysis for each probability. SETTING: Health-care workers infected with multidrug-resistant strains of M tuberculosis. INTERVENTIONS: Prophylaxis with ciprofloxacin and pyrazinamide. MEASUREMENTS AND RESULTS: We calculated the utilities of taking or not taking prophylaxis with ciprofloxacin and pyrazinamide. The decision analysis favored the use of ciprofloxacin-pyrazinamide prophylaxis by a small margin. CONCLUSION: Ciprofloxacin-pyrazinamide prophylaxis should be considered for health-care workers infected with multiply drug-resistant M tuberculosis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7656621&dopt=Abstract
Chemotherapy. 1986;32(5):446-52.
Comparative in vitro activity of ciprofloxacin and other antimicrobial agents against aminoglycoside-resistant gram-negative rods and microorganisms isolated from patients with bacteremia.
Weinstein MP.
The comparative in vitro activity of ciprofloxacin, norfloxacin, aztreonam, cefotaxime, ceftazidime, mezlocillin, azlocillin, and tobramycin was evaluated against 188 isolates from bacteremic patients and 161 aminoglycoside-resistant gram-negative rods. Although some streptococcal (particularly enterococcal) blood isolates, Pseudomonas spp., and nonfermentative gram-negative rods were not inhibited by ciprofloxacin, it was nevertheless the most active compound tested against both microorganism groups.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3757586&dopt=Abstract
J Pak Med Assoc. 1995 Jun;45(6):147-50.
Ciprofloxacin in multi-resistant infections in childhood: an audit.
Khan DM, Bhutta ZA.
Department of Paediatrics, Aga Khan University, Karachi.
Ciprofloxacin is a new orally administrable fluoroquinolones, with considerable efficacy against multiresistant organisms. Its use in the paediatric age group however, is controversial because of the risk of potential articular toxicity. We retrospectively reviewed ciprofloxacin usage over a 32 week periods (June, 1991-September, 1993) in paediatric inpatients at The Aga Khan University Hospital. Ciprofloxacin was used in 21 cases, singly in 11 (52%) and in combination with other antibiotics in a further 10 (48%). The response to therapy was adjudged as 'good' or 'fair' in 13 (62%) cases. Ciprofloxacin was the only sensitive antibiotic in 4 (19%) and resistance to it was detected in another 4 (19%) cases. Despite all efforts, adequate follow-up could only be achieved in a third of the patients. Although no toxic or side effects were detected, in view of poor follow-up and emergence of ciprofloxacin resistant strains, our experience highlights the need to regulate ciprofloxacin use in the paediatric age group.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7474287&dopt=Abstract
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