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Antimicrob Agents Chemother. 1984 Mar;25(3):342-3.
Effect of inoculum, pH, and medium on the activity of ciprofloxacin against anaerobic bacteria.

Borobio MV, Perea EJ.

The in vitro activity of ciprofloxacin against 30 Bacteroides fragilis group, 30 Clostridium, and 30 Peptococcaceae strains was determined by the agar dilution method in two different culture media at three pH and in three inoculum densities. In Wilkins-Chalgren agar the MICs for 90% of the strains were 0.12 micrograms/ml for B. fragilis, 0.5 micrograms/ml for Clostridium spp., and 2 micrograms/ml for Peptococcaceae. The pH and medium composition affected the MICs of ciprofloxacin.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6721466&dopt=Abstract




J Assoc Physicians India. 1994 Aug;42(8):599-600.
A study of culture positive multidrug resistant enteric fever--changing pattern and emerging resistance to ciprofloxacin.

Daga MK, Sarin K, Sarkar R.

Dept of Medicine, Maulana Azad Medical College, New Delhi.

The present prospective study was carried out to observe the changing trends in the clinical pattern and multidrug resistance in typhoid fever. Fever was the main presenting feature. Other associated features were headache, vomiting, diarrhoea, altered sensorium and jaundice. Out of 78 patients, one patient died due to enteric encephalopathy and other due to septicaemia with peripheral circulatory failure. 12 patients responded to chloramphenicol and gentamycin. 51 patients responded to ciprofloxacin, while remaining 9 patients responded to combination of cefotaxime and amikacin. Three patients showed in vitro resistance to ciprofloxacin and two out of these also showed no response in vivo. This study re-emphasises the changing pattern, prolonged course and role of quinolones especially ciprofloxacin in the management of drug resistant typhoid fever, but at the same time indicates that ciprofloxacin is not the drug of choice in all cases of typhoid fever and resistance to it may be seen in some cases, where other drugs have to be used.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7868549&dopt=Abstract




Eur J Clin Microbiol Infect Dis. 1995 Mar;14(3):193-8.
Study of Stomatococcus mucilaginosus isolated in a hospital ward using phenotypic characterization.

van Tiel FH, Slangen BF, Schouten HC, Jacobs JA.

Department of Medical Microbiology, Maastricht University Hospital, The Netherlands.

Thirty-one isolates of Stomatococcus mucilaginosus were cultured from the blood (n = 6), throat (n = 23) and sputum (n = 2) of 18 hospitalized patients, 13 of whom were neutropaneic and five of whom were non-neutropaneic. Antibiotic susceptibility testing, performed by means of a broth microdilution method, showed that the minimal inhibitory concentrations (MICs) of ciprofloxacin were > or = 4 mg/l for the isolates collected from neutropaenic patients. All these patients received ciprofloxacin as part of their prophylactic regimen. In contrast, the MICs for four of five isolates collected from non-neutropaenic patients, none of whom were receiving ciprofloxacin, were < or = 2 mg/l. In addition, 14 of the 31 isolates were cultured from seven neutropaenic patients, admitted to the same ward over a 12-week period. To evaluate possible cross-acquisition of strains between patients, cluster analysis of all 31 isolates was performed using phenotypic characteristics, MIC values and acid production from carbohydrates (API 50 CH). Overall, 22 isolate clusters were distinguished. In five of 18 patients, two or more isolates were cultured which belonged to different clusters. In only one patient, identical isolates were cultured from blood and from the throat. All six isolates of cluster 7 were cultured within the aforementioned 12-week period from three neutropaenic patients. These data support the possibility of cross-acquisition of strains between patients although its frequency seems to be low.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7614959&dopt=Abstract













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