Drugs online research references
HNO. 1986 Dec;34(12):511-4.
[Gyrase inhibitor in the local treatment of the chronically infected middle ear following surgery]
[Article in German]
Ganz H.
Local treatment of 20 chronic bacterial ear infections (18 infected radical cavities, 2 external otitis) with a gyrase inhibitor (Ciprofloxacin) solution led to clinical resolution in 17 cases, with elimination of the causative organisms in 16 cases. No side effects were seen, but a resistant pseudomonas developed in one case, and candida albicans in 8 others. Gyrase inhibitors such as Ciprofloxacin are antibiotics of second choice. For local treatment in the ear they should be used only in difficult cases and exclusively by the otologist. This treatment must not be used to replace proper cleaning of the ear or a necessary operation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3028994&dopt=Abstract
Diagn Microbiol Infect Dis. 1989 May-Jun;12(3 Suppl):17S-20S.
In vitro activity of lomefloxacin as compared with ciprofloxacin.
Inderlied CB, Lancero MG, Bermudez LM, Young LS.
Department of Pathology, University of Southern California, Los Angeles 90027.
Lomefloxacin (SC47111, Searle) is a difluorinated quinolone with a comparatively long half-life and high serum concentration. This agent has good in vitro activity against Enterobacteriaceae (MIC90 = less than 2 micrograms/ml) and staphylococci (MIC90 = less than 2 micrograms/ml); the activity against Pseudomonas spp. and Pseudomonas aeruginosa is moderate to poor. On a weight basis, lomefloxacin is less active than ciprofloxacin; however, based on the ratio of the serum concentration to MIC, the activity of lomefloxacin is nearly equivalent to ciprofloxacin against many bacteria, with the exception that ciprofloxacin has good activity against most pseudomonads. Also, lomefloxacin was active against a variety of bacteria that were resistant to aminoglycosides and/or third-generation cephalosporins. A majority of strains of the Mycobacterium avium complex, isolated from AIDS patients with disseminated disease, were found to be resistant to lomefloxacin (MIC90 = greater than 8 micrograms/ml).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2791493&dopt=Abstract
Diagn Microbiol Infect Dis. 1989 May-Jun;12(3 Suppl):87S-88S.
In vitro activity of lomefloxacin (SC 47111 or NY-198) against Chlamydia trachomatis strains.
Segreti J, Kessler HA, Kapell K, Trenholme GM.
Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
The in vitro activity of lomefloxacin (SC 47111 or NY-198), a new quinolone antibiotic, against 11 strains of Chlamydia trachomatis was determined and compared to doxycycline, norfloxacin, and ciprofloxacin. Lomefloxacin had anti-chlamydial activity comparable to that of ciprofloxacin. (MIC and MBC90, 2 micrograms/ml).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2791503&dopt=Abstract
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