Drugs online research references
Pathol Biol (Paris). 1988 May;36(5):403-9.
[Comparative bactericidal kinetics of ciprofloxacin, ofloxacin and pefloxacin alone and in combination against strains of group D Streptococcus]
[Article in French]
Zuccarelli M, Simeon de Buochberg M, Maillols M, Armynot du Chatelet AM, Attisso MA.
Laboratoire de Bacteriologie et Biologie cellulaire, Faculte de Pharmacie, Montpellier.
Killing curves method was used to study bactericidal activity of the three quinolones, alone and in combination with penicillin, amoxicillin, fosfomycin, netilmicin, vancomycin against six isolates of enterococci. Alone, ofloxacin showed the most initial bactericidal effect but ciprofloxacin was the most frequently bactericidal without any regrowth in 24 hours. The combinations with beta-lactams and netilmicin were sometimes synergistic in 24 hours; fosfomycin increased initial bactericidal effect.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3136422&dopt=Abstract
Acta Pathol Microbiol Immunol Scand [B]. 1987 Jun;95(3):199-202.
Post-antibiotic effect and killing activity of ciprofloxacin against Staphylococcus aureus.
Fuursted K.
The effect of ciprofloxacin on eight strains of Staphylococcus aureus were examined. A post-antibiotic effect was observed in all strains, varying between 1.65 and 2.75 hours, with concentration of ciprofloxacin at 5 times the Minimum Inhibitory Concentration (MIC) exposed for 1 hour. Killing-kinetic studies at 5 times the MIC showed a decrease in the numbers of organisms by approximately 2.1 log10 after 6 hours, independent of the growth phase. A significantly increased susceptibility of S. aureus to the bactericidal activity of ciprofloxacin during recovery from the PAE-phase was demonstrated.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3630713&dopt=Abstract
Radiat Res. 1990 May;122(2):215-7.
Quinolone therapy of Klebsiella pneumoniae sepsis following irradiation: comparison of pefloxacin, ciprofloxacin, and ofloxacin.
Brook I, Elliott TB, Ledney GD.
Experimental Hematology Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland.
Exposure to whole-body irradiation is associated with fatal gram-negative sepsis. The effect of oral therapy with three quinolones, pefloxacin, ciprofloxacin, and ofloxacin, for orally acquired Klebsiella pneumoniae infection was tested in B6D2F1 mice exposed to 8.0 Gy whole-body irradiation from bilaterally positioned 60Co sources. A dose of 10(8) organisms was given orally 2 days after irradiation, and therapy was started 1 day later. Quinolones reduced colonization of the ileum with K. pneumoniae: 16 of 28 (57%) untreated mice harbored the organisms, compared to only 12 of 90 (13%) mice treated with quinolones (P less than 0.005). K. pneumoniae was isolated from the livers of 6 of 28 untreated mice, compared to only 1 of 90 treated mice (P less than 0.001). Only 5 of 20 (25%) untreated mice survived for at least 30 days compared with 17 of 20 (85%) mice treated with ofloxacin, 15 of 20 (75%) mice treated with pefloxacin, and 14 of 20 (70%) treated with ciprofloxacin (P less than 0.05). These data illustrate the efficacy of quinolones for oral therapy of orally acquired K. pneumoniae infection in irradiated hosts.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2186431&dopt=Abstract
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