Drugs online research references
J Pharm Biomed Anal. 1997 Nov;16(3):439-45.
Isolation and structure elucidation of an intermediate in the photodegradation of ciprofloxacin.
Torniainen K, Askolin CP, Mattinen J.
Turku University Central Hospital, Hospital Pharmacy, Finland.
Ciprofloxacin decomposes photochemically in aqueous solutions at acidic pH forming two major degradation products. One of the products, isolated from irradiated solutions by flash chromatography, was 7-[(2-aminoethyl)amino]-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-3-quinoline carboxylic acid. The compound was an intermediate in the photochemical process, which degraded after longer exposure with a high-pressure mercury lamp to an aromatic amino-compound, 7-amino-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-3-quinoline carboxylic acid. The structure of the intermediate was elucidated on the basis of information from ultraviolet, mass and nuclear magnetic resonance spectra.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9589402&dopt=Abstract
Arzneimittelforschung. 1986 Oct;36(10):1545-9.
Isolation and structural elucidation of urinary metabolites of ciprofloxacin.
Gau W, Kurz J, Petersen U, Ploschke HJ, Wuensche C.
After oral administration of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-1-ylquinoline++ +-3-carboxylic acid (ciprofloxacin, Bay o 9867; designated trademark: Ciprobay) four metabolites M1-M4 were isolated from human urine by Craig counter current distribution and semipreparative high-performance liquid chromatography. Their molecular structures were elucidated by nuclear magnetic resonance and mass spectrometry and confirmed by comparing their spectra with those of authentic synthetic reference compounds.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3814216&dopt=Abstract
J Assoc Physicians India. 1994 Feb;42(2):124-5.
Choice of antibiotics for empiric treatment of serious infections.
Gupta BL, Singh S, Rattan A, Bhujwala RA.
Department of Microbiology, AIIMS, Ansari Nagar, New Delhi.
We have compared the in vitro activity of commonly used aminoglycosides--Gentamicin and Amikacin with Ciprofloxacin to determine whether the latter has any role in the empiric treatment of serious bacterial infections. Our results indicate that ciproloxacin was comparable or had a better activity than gentamicin or Amikacin against clinical isolates. As it can be administered orally, hospitalization can be avoided in a large number of patients.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7860472&dopt=Abstract
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