Drugs online research references
Mutat Res. 1990 Apr;243(4):267-72.
Expression of the recA gene is reduced in Escherichia coli topoisomerase I mutants.
Urios A, Herrera G, Aleixandre V, Blanco M.
Instituto de Investigaciones Citologicas de la Caja de Ahorros de Valencia, Spain.
We studied the influence of DNA topological changes on Escherichia coli recA gene expression. This was monitored by measuring beta-galactosidase activity in cells containing a recA-lacZ fusion. To modulate DNA supercoiling we used mutations in the genes encoding for topoisomerase I and DNA gyrase. After either UV irradiation or treatment with the gyrase inhibitor ciprofloxacin, induction of the recA gene was reduced in topA10 mutants, this reduction being alleviated when gyrA or gyrB mutations causing DNA relaxation were present. A reduced induction of recA was also observed after incubation of cells carrying the recA441 mutation at 42 degrees C in the presence of adenine. Using bacteria deficient in the LexA repressor, we have demonstrated that the topA10 mutation reduces the constitutive expression of the recA gene. We suggest that the increase in negative supercoiling resulting from topoisomerase I deficiency interferes with transcription from the recA promoter. The reduction in the expression of the recA gene in topA10 bacteria could determine their increased UV sensitivity as well as their partial defectiveness in SOS mutability.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2157980&dopt=Abstract
Vutr Boles. 1989;28(5):20-4.
[Ciprofloxacin in bacterial infections]
[Article in Bulgarian]
Belovezhdov N, Monova D.
42 patients with bacterial infections caused by resistant to other available in this country antibiotics, immunocompromised patients and patients in severe life-threatening conditions were treated with ciprofloxacin (Ciprobay--Bayer) in tablets. Before being admitted to the clinic most of the patients had been treated with various antibacterial drugs, including Tarivid--Hoechst (4 patients), in sufficient doses and duration. The drug was applied in doses of 250 mg or 500 mg twice daily according to the type, site, severity of the infection and the renal function state. The treatment continued for 5 up to 10 days. The results were judged by a three degree scale. In 37 patients (88.1%) the results were considered very good and in 5 patients (11.9%)--good. The side effects were insignificant. Ciprofloxacin emerges as a strong antibacterial drug with a very good therapeutic efficacy in patients with severe infections of the urinary tract and other organs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2618005&dopt=Abstract
Eur J Clin Microbiol. 1986 Apr;5(2):232-5.
Evaluation of ciprofloxacin in the treatment of Pseudomonas aeruginosa infections.
Giamarellou H, Galanakis N, Dendrinos C, Stefanou J, Daphnis E, Daikos GK.
The efficacy and safety of ciprofloxacin in the treatment of Pseudomonas aeruginosa infections was evaluated in 72 patients suffering from upper urinary tract infection (19 patients), deep soft tissue infection (16), chronic osteomyelitis (12), abscess (7), chronic otitis media (6), otitis externa (3) and bronchopneumonia (9). Forty-eight patients received an oral dose of 500 mg or 750 mg b.i.d. and five patients an i.v. dose of 200 mg b.i.d., while 19 patients were given both oral and parenteral doses. The duration of therapy ranged from seven days to more than four months. The MICs of ciprofloxacin for the Pseudomonas aeruginosa strains isolated were in the range less than 0.06-2 mg/l; 36% of the strains were resistant to all other available antibiotics. At follow-up after a minimum of six months the clinical success rate was 75% and the infecting organism was permanently eradicated in 49% of the patients. In nine patients the organism developed resistance, particularly when the initial MIC was higher than 0.5 mg/l. No significant adverse reactions were observed. Ciprofloxacin is the first antipseudomonal antimicrobial agent which can be administered orally and therefore fulfills a need in chemotherapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2941288&dopt=Abstract
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