Drugs online research references
Antimicrob Agents Chemother. 1997 Jul;41(7):1547-51.
Differential intracellular efficacies of ciprofloxacin and cefixime against Neisseria gonorrhoeae in human fallopian tube organ culture.
Phanucharas JP, Gorby GL.
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68131, USA.
This study compared the abilities of ciprofloxacin and cefixime to kill intracellular Neisseria gonorrhoeae in a human fallopian tube organ culture assay. When invasion was inhibited by cytochalasin D, 0.996% of the tissue-associated gonococci survived ciprofloxacin exposure compared to 1.70% of gonococci exposed to cefixime (95% confidence interval for the ratio of the means, 0.267 to 1.30), indicating that the two antibiotics did not significantly differ in the ability to kill extracellular attached organisms. In the absence of cytochalasin D, 1.63% survived ciprofloxacin exposure while 9.76% survived cefixime treatment (95% confidence interval for the ratio of the means, 0.067 to 0.418). These results suggest that ciprofloxacin penetrated epithelial cells and killed intracellular gonococci better than did cefixime. Thus, at concentrations achievable in serum, ciprofloxacin was more effective in total gonococcal killing than cefixime in this human fallopian tube organ culture model.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9210682&dopt=Abstract
Diagn Microbiol Infect Dis. 1987 Jan;6(1):49-52.
In vitro activity of efrotomycin, ciprofloxacin, and six other antimicrobials against Clostridium difficile.
Clabots CR, Shanholtzer CJ, Peterson LR, Gerding DN.
The susceptibility of 69 clinical isolates of Clostridium difficile from the Minneapolis Veterans Administration Medical Center and 29 C. difficile strains from other hospitals to efrotomycin, ciprofloxacin, and six other antimicrobials was tested in vitro by agar dilution. Ciprofloxin (MIC50 and MIC90 = 8 mcg/ml) was only moderately active whereas efrotomycin (MIC50 = 0.125, MIC90 = 0.25 mcg/ml) was highly active against C. difficile.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3802745&dopt=Abstract
Antimicrob Agents Chemother. 1989 Jan;33(1):108-9.
Comparative in vitro activities of six new fluoroquinolones and other oral antimicrobial agents against Campylobacter pylori.
Simor AE, Ferro S, Low DE.
Department of Microbiology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
The in vitro susceptibilities of 56 clinical isolates of Campylobacter pylori to six new fluoroquinolones and other oral antimicrobial agents were determined by an agar dilution technique. Ciprofloxacin was the most active of the fluoroquinolones (MIC for 90% of strains tested [MIC90], 0.05 microgram/ml). Other fluoroquinolones had variable activities, although most isolates were moderately susceptible to fleroxacin (MIC90, 4 micrograms/ml) and lomefloxacin (MIC90, 4 micrograms/ml).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2712542&dopt=Abstract
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