Online Pharmacy, Tramadol, Paxil, antibiotics, amoxicillin, zithromax, Rx Online, pharmaceuticals, DHEA, prescription medications, prescription drugs.

Drugs online research references

J Pharmacol Exp Ther. 1988 Feb;244(2):531-6.
Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea.

Dusser DJ, Nadel JA, Sekizawa K, Graf PD, Borson DB.

Cardiovascular Research Institute, University of California, San Francisco.

Neutral endopeptidase (NEP) (enkephalinase, EC 3.4.24.11) and angiotensin converting enzyme (ACE) are two peptidases that can cleave the C-terminal dipeptide bradykinin(8-9) from bradykinin. To determine whether these peptidases play roles in modulating kinin-induced contractions in the airways, we studied the effects of captopril, an ACE inhibitor, and of leucine-thiorphan and phosphoramidon, two NEP inhibitors, on the contractile responses to bradykinin and lysyl-bradykinin in isolated segments of ferret trachea. Bradykinin and lysyl-bradykinin-induced contractions in a concentration-dependent fashion (P less than .001), with a threshold of 10(-7) M and 5 x 10(-7) M, respectively. In contrast, the bradykinin(8-9) and the N-terminal heptapeptide bradykinin(1-7), the major fragments of hydrolysis of bradykinin by NEP and ACE, had a very weak or no effect on tracheal contraction in concentrations as great as 10(-5) M. Captopril, leucine-thiorphan and phosphoramidon (each inhibitor at 10(-5) M, 15 min) shifted the concentration-response curves to lower concentrations by approximately 1 to 1.5 log U (P less than .05). Both NEP inhibitors and the ACE inhibitor potentiated the response to bradykinin in a concentration-dependent fashion (P = .0001), and the combination of phosphoramidon and captopril resulted in an additive potentiation of bradykinin-induced contraction (P less than .02). [D-Pro2-D-Trp7,9]-substance P, a substance P antagonist, did not modify the potentiation of bradykinin-induced contraction by NEP inhibitors.(ABSTRACT TRUNCATED AT 250 WORDS)

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3279179&dopt=Abstract

Med Sci Monit. 2000 May-Jun;6(3):491-7.
An attempt to assess the central action of captopril and enalaprilat.

Czarnecka E, Strzelec J, Pietrzak B.

Department of Pharmacodynamics, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.

The influence of captopril and enalaprilat on central nervous system in laboratory animals has been studied. The effects of the drugs on duration of ethanol (4 g/kg i.p.) and thiopental (70 mg/kg i.p.) induced sleep, body temperature, spontaneous locomotor activity and analgesic properties (hot plate and tail-flick test) have been investigated in mice. Captopril (5 and 20 mg/kg i.p.) and enalaprilat (5 and 20 mg/kg i.p.) were used in single administration or repeated one for 10 days. Moreover, pharmaco-EEG profile of captopril and enalaprilat in rabbits has been studied. We have shown that single administration of captopril (both doses) and single or prolonged administration of enalaprilat decreased the duration of ethanol and thiopental-induced sleep. Captopril (5 mg/kg) and enalaprilat (5 and 20 mg/kg) increased pain threshold. Both studied drugs after their single or repeated administration did not influence spontaneous locomotor activity in mice. Captopril and enalaprilat decrease body temperature in mice. Examined ACEIs produce changes in EEG recording, more profoundly exhibited after administration of enalaprilat.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11208359&dopt=Abstract

Hypertension. 2001 Jan;37(1):28-33.
Vasopeptidase Inhibition Prevents Endothelial Dysfunction of Resistance Arteries in Salt-Sensitive Hypertension in Comparison With Single ACE Inhibition.

d'Uscio LV, Quaschning T, Burnett JC Jr, Luscher TF.

Cardiovascular Research, Institute of Physiology, University Zurich, and Division of Cardiology, University Hospital (L.V.d'U., T.Q., T.F.L.), Zurich, Switzerland.

-To determine whether natriuretic peptides in addition to the renin-angiotensin system are involved in functional and structural vascular changes in salt-sensitive hypertension, we compared equipotent hypotensive treatment with the dual neutral endopeptidase/ACE inhibitor omapatrilat (35 mg. kg(-1). d(-1)) or the ACE inhibitor captopril (100 mg. kg(-1). d(-1)). The reactivity and geometry of mesenteric resistance arteries from Dahl salt-sensitive rats were studied in vitro under perfused and pressurized conditions. Chronic salt administration increased systolic blood pressure by 57+/-4 mm Hg, whereas concentrations of atrial natriuretic peptide were reduced in heart and in plasma (P:<0.05). In addition, the medial cross-sectional area of small mesenteric arteries was increased and endothelium-dependent relaxation in response to acetylcholine and contraction in response to endothelin-1 were impaired in the mesenteric arteries of salt-sensitive rats on a high-salt diet (P:<0.05). Concomitant treatment with either omapatrilat or captopril reduced the increase in systolic blood pressure and hypertrophic remodeling to a similar degree (P:<0.05) but affected plasma and cardiac atrial natriuretic peptide levels differently (P:<0.05). In addition, omapatrilat normalized endothelium-dependent relaxations to a greater extent than captopril (P:<0.05). Furthermore, vasopeptidase inhibition increased cGMP levels compared with captopril (P:<0.05). Contractions to endothelin-1 were normalized by either antihypertensive drug. These results suggest that in the Dahl rat, with similar reductions in systolic blood pressure, omapatrilat is superior to captopril in preventing impaired endothelial function in small resistance arteries. Thus, vasopeptidase inhibition may have therapeutic advantages of the prevention of changes in vascular function and structure in salt-sensitive forms of hypertension.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11208752&dopt=Abstract [PubMed - as supplied by publisher]

online pharmacies || Hair Million herbal formula for hair loss and hair growth || Amoxicillin || Tramadol || Paxil || Rx Drugs USA, Prescription Drugs Online Pharmacy || Zithromax || online pharmacy || Antibiotics and prescription medications online literature || Antibiotics