Drugs online research references
Insect Biochem Mol Biol. 2001 Jan;31(1):87-95.
In vitro degradation of the Neb-Trypsin modulating oostatic factor (Neb-TMOF) in gut luminal content and hemolymph of the grey fleshfly, Neobellieria bullata.
Zhu W, Vandingenen A, Huybrechts R, Baggerman G, De Loof A, P Poulos C, Velentza A, Breuer M.
Zoological Institute, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium.
The unblocked hexapeptidic Trypsin Modulating Oostatic Factor of the fleshfly, an inhibitor of both trypsin and ecdysone biosynthesis, resists very well proteolytic breakdown by enzymes present in the lumen of the gut of previtellogenic fleshflies. However, when incubated in hemolymph of adult flies, females and males, its half-life time is a mere 0.5 min. In hemolymph of last instar larvae, this value increases to about 1.5 min. Whereas PMSF, a potent inhibitor of serine proteases has no effect, captopril and lisinopril, both known to be specific inhibitors of mammalian angiotensin I converting enzyme (ACE), effectively inhibit TMOF breakdown in fly hemolymph. Digestion of Neb-TMOF by recombinant Drosophila AnCE on itself results in identical degradation products as with total hemolymph. In both cases ESI-Qq-oa-Tof mass spectrometry demonstrated the appearance of peptide fragments with the sequences NPTN, LH and NP. These observations not only confirm the reported presence of circulating ACE-like activity in flies but also strongly suggest that in flies this hemolymph ACE-like activity might be involved in the regulation of the oostatic activity as exerted by Neb-TMOF.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11102838&dopt=Abstract
MedGenMed. 1999 Nov 4;:E33.
Dysgeusia by Losartan in a Patient Intolerant of Captopril.
Malnick SD, Becker S.
Kaplan Medical Center.
PMID: 11104435 [PubMed - as supplied by publisher]
Int J Cardiol. 2000 Nov-Dec;76(2-3):227-33.
Effectiveness of low dose captopril versus propranolol therapy in infants with severe congestive failure due to left-to-right shunts.
Buchhorn R, Ross RD, Hulpke-Wette M, Bartmus D, Wessel A, Schulz R, Bursch J.
Department of Pediatric Cardiology, Children's Medical Center, Georg-August-University, Gottingen, Germany. rbuchho
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