Drugs online research references
Vnitr Lek. 1991 Jul-Aug;37(7-8):625-32.
[Isosorbide dinitrate tolerance in the treatment of patients with angina pectoris and the effect of addition of captopril on therapeutic results]
[Article in Czech]
Rotrekl P, Lupinek Z, Meluzin J, Novak M.
I. klinika vnitrnich chorob lekarske fakulty Masarykovy univerzity, Brno-Bohunice.
The authors investigated in patients with stable angina the influence of a single dose and of long-term administration of isosorbide dinitrate alone and combined with captopril. Administration of 40 mg Iso-Mack ret. every 8 hours for four weeks did not lead to the development of tolerance. However, captopril added to isosorbide dinitrate tends to improve the investigated indicators after a single dose as well as after long-term treatment. It is probable that concurrent administration of the two drugs causes addition of their vasodilatating action and thus the vascular resistance declines, as well as the cardiac pre-load and after-load and the oxygen consumption of the heart muscle. The authors discuss possible mechanisms of the increased vasodilatation after addition of captopril.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1755201&dopt=Abstract
Clin Ter. 1986 Jul 15;118(1):33-6.
[Long-term efficacy and tolerability of captopril in the therapy of arterial hypertension]
[Article in Italian]
Vincenzi V, Bartolucci L, Fioroni E, Gradoli C, Peciarolo A, Valori C.
PMID: 3527538
Am J Physiol. 1989 Oct;257(4 Pt 2):H1315-20.
Modulation of vascular tone by neutrophils: dependence on endothelial integrity.
Mehta JL, Lawson DL, Nichols WW, Mehta P.
Department of Medicine, University of Florida College of Medicine, Gainesville 32610.
To determine the influence of polymorphonuclear leukocytes (PMNLs) on vascular smooth muscle tone, isolated human PMNLs (10(4)-10(7) cells/ml) were suspended in a tissue bath with precontracted rat aortic rings with or without endothelium. PMNLs in low concentrations (10(4) and 10(5) cells/ml) caused a mild contraction, and in higher concentrations (10(6) and 10(7) cells/ml) caused a modest relaxation of aortic rings with intact endothelium. In contrast, PMNLs caused a potent concentration-dependent relaxation of deendothelialized rings (P less than 0.01 compared with rings with intact endothelium). The PMNL-induced vascular smooth muscle relaxation was abolished by both hemoglobin and methylene blue and potentiated by both superoxide dismutase and captopril. Although suspension of PMNLs caused release of eicosanoids, thromboxane A2 and prostacyclin, from rings with intact endothelium, neither indomethacin nor the TxA2-endoperoxide receptor antagonist SQ 29548 modified the effects of PMNLs on vascular smooth muscle tone. These observations suggest that unstimulated PMNLs generate a smooth muscle relaxant, which has biological characteristics similar to the endothelium-derived relaxing factor. Since the activity of this PMNL-derived smooth muscle relaxant is more pronounced in deendothelialized vascular segments, it appears that endothelium provides a barrier against vasorelaxation by high concentrations of PMNLs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2508493&dopt=Abstract
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