Drugs online research references
Acta Med Scand Suppl. 1983;677:141-2.
Reduction of sodium taste threshold during treatment with captopril in essential hypertension.
Fyhrquist F, Gronhagen-Riska C, Saloranta K.
PMID: 6367373
Ann Thorac Surg. 1993 Jul;56(1 Suppl):S54-60.
Studies on the use of thyroid hormone and a thyroid hormone analogue in the treatment of congestive heart failure.
Morkin E, Pennock GD, Raya TE, Bahl JJ, Goldman S.
Department of Cardiology, Tucson Veterans Administration Medical Center, Arizona.
In heart failure, cardiac output is insufficient to meet the needs of the body for oxygen delivery. Available data suggest that alterations in thyroid hormone metabolism may contribute to defective myocardial performance. Accordingly, thyroid hormone or a thyroid hormone analogue that improves cardiac performance might be useful in the treatment of heart failure and has been studied. Experimental and theoretical results of these studies are reviewed and indicate that thyroid hormone increases cardiac output by a combination of effects on the heart and peripheral circulation, specifically by increasing myocardial contractile performance and decreasing venous compliance. In the rat postinfarction model of heart failure, treatment with low doses of thyroxine (1.5 micrograms/100 g) for 3 days produced a positive inotropic response, including an increase in rate of change of left ventricular pressure and a decrease in left ventricular end-diastolic pressure. These changes could be attributed to conversion to triiodothyronine, the active intracellular form of thyroid hormone. When treatment with thyroxine was continued at the same or higher doses (3 to 15 micrograms/100 g) for 10 to 12 days, heart rate increased and improvement in left ventricular end-diastolic pressure was not sustained. More favorable results were obtained with 3,5-diiodothyropropionic acid, a cardiotonic thyroid hormone analogue administered at doses of 375 microgram/100 g, given in combination with captopril. Thus, triiodothyronine or a thyroid hormone analogue may be a useful adjunct to other measures in the treatment of heart failure.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8333798&dopt=Abstract
Acta Pharm Hung. 1993 Jan;63(1):13-8.
2-Iodoxybenzoate as a titrant for the determination of some pharmaceutically-important thiol compounds.
Rizk MS, Belal F, Eid MM.
Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
A simple and reliable method was developed for the determination of five pharmaceutical compounds containing thiol group; namely: N-acetylcysteine, D-penicillamine, 6-mercaptopurine, captopril and thioguanine. The method is based on the use of 2-iodoxybenzoate as a titrant in acid medium. The detection of the end point is accomplished potentiometrically, using platinum/calomel electrode combination. For all the studied compounds, the stoichiometry of the reaction was found to be 2:3 suggesting that, the thiol group is oxidised to the corresponding sulphonic acid. This finding was confirmed through TLC study of the reaction products. The proposed method was successfully applied to the determination of the studied compounds in dosage forms and the results were in good agreement with those given using the official methods.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8452030&dopt=Abstract
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