Drugs online research references
Ned Tijdschr Geneeskd. 1980 Nov 22;124(47):1996-2003.
[A new point of attack for the treatment of hypertension; captopril, an orally active inhibitor of the enzymatic conversion of angiotensin I into angiotensin II]
[Article in Dutch]
Schalekamp MA, de Bruyn JH, Wenting GJ, Man in 't Veld AJ, Derkx FH.
PMID: 6255350
Fed Proc. 1984 Jan;43(1):72-7.
Effect of antihypertensive therapy on sympathetic nervous system activity in patients with essential hypertension.
Chernow B, Zaloga GP, Lake CR, Coleman MD, Ziegler MG.
The sympathetic nervous system (SNS) plays a major role in blood pressure regulation. Although the exact relationship of the SNS to the etiology of hypertension remains undetermined, many of the agents used to treat hypertension interfere with this system. Clonidine, methyldopa, guanethidine, and reserpine decrease SNS tone whereas hydralazine, minoxidil, and hydrochlorothiazide increase it. Most evidence suggests that beta-adrenergic blocking agents decrease SNS activity. The effect of prazosin and captopril on the SNS requires further study. The appropriate use of these antihypertensive agents requires a knowledge of their sites of action and the physiological reflexes they induce. Efficacy, toxicity, and effective drug combinations can be predicted based on their mechanism of action and effect on SNS activity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6317467&dopt=Abstract
Dev Pharmacol Ther. 1991;16(4):185-93.
Captopril pharmacokinetics, blood pressure response and plasma renin activity in normotensive children with renal scarring.
Levy M, Koren G, Klein J, McLorie G, Balfe JW.
Department of Pediatrics, Hospital for Sick Children, Toronto, Ont., Canada.
We studied blood pressure response, plasma renin activity (PRA) and captopril pharmacokinetics in 8 children receiving orally 0.7 mg/kg of the drug. The drug increased PRA in all patients, in 5 to abnormally high levels. Peak captopril concentrations were achieved between half an hour and 2 h, and ranged between 100 and 547 ng/ml. Mean elimination half-time (T1/2) was 1.5 h, ranging between 0.98 and 2.3 h. There was a significant positive correlation between the area under the curve (AUC) and elimination T1/2 of the drug. There was a significant inverse correlation between AUC or elimination T1/2 and percent change in diastolic blood pressure; the 2 children who had no change in diastolic blood pressure had the largest AUC and the lowest apparent clearance of captopril. The kidney is the major site of captopril's pharmacological action. It is possible that longer retention of captopril in the plasma, evidence by larger AUC, may reflect less captopril available to modulate renin activity in the kidney.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1782836&dopt=Abstract
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