Drugs online research references
Arch Int Pharmacodyn Ther. 1983 May;263(1):40-9.
Effect of beta-adrenergic blockers on isolated coronary arterial strip and tracheal smooth muscle of pig.
Agarwal OP, Sharma JN, Siddiqui HH.
Isolated coronary arterial strip and tracheal smooth muscle of pig, containing predominantly beta 1- and beta 2-adrenoceptors respectively, have been used for estimating the comparative potency of nine beta-adrenergic blocking agents. The order of potency of the antagonists on the isolated coronary arterial strip was propranolol greater than alprenolol greater than H 64/52 greater than H 64/55 greater than practolol greater than H 87/07 greater than atenolol greater than metoprolol greater than H 35/25, whilst the order of potency on the pig tracheal smooth muscle was alprenolol greater than propranolol greater than H 35/25 greater than H 87/07 greater than H 64/55 greater than H 64/52 greater than metoprolol greater than practolol greater than atenolol. Propranolol and alprenolol were almost equipotent in both the preparations and hence were nonspecific. Although practolol, metoprolol, H 64/55 and H 87/07 were beta 1-selective, their selectivity ratio was comparatively smaller than that of atenolol and H 64/52. The study indicates that H 64/52 and atenolol are the most specific beta-adrenergic blocking agents on isolated coronary arterial strip of pig and that their beta 1/beta 2-ratios are 126 and 120 respectively. H 64/52 like atenolol may be of therapeutic value in cardiovascular disorders.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6137200&dopt=Abstract
Am J Physiol. 1984 Aug;247(2 Pt 2):H330-6.
Effect of beta-adrenergic blockade on nucleoside release from the hypoperfused isolated heart.
Wangler RD, DeWitt DF, Sparks HV Jr.
Myocardial ischemia increases the release of adenosine (RADO), inosine (RINO), and norepinephrine; however, it is not known whether norepinephrine contributes to nucleoside production via the beta-adrenergic receptor. We used a Langendorff preparation (guinea pig) to study the time course of RADO and RINO during myocardial hypoperfusion (MH) produced by decreasing perfusion pressure from 60 to 30 cmH2O. Data are expressed as means +/- SE. RADO and RINO significantly increased from 21 +/- 2 and 418 +/- 89 pmol X min-1 X g-1 to 206 +/- 26 and 2,401 +/- 598, respectively, by 10 min of MH. By 20 min, RADO and RINO had decreased significantly to 111 +/- 15 and 912 +/- 169 pmol X min-1 X g-1. RADO remained at that level for the remaining 160 min, whereas RINO returned to the control level. Coronary flow and myocardial O2 consumption were constant during MH. In the presence of 10(-7) M dl-propranolol MH did not produce the initial peak RADO; RADO increased to 95 +/- 18 pmol X min-1 X g-1 at 10 min and then did not change. Also, the initial peak RINO was significantly reduced (687 +/- 67 pmol X min-1 X g-1 at 10 min). Similar results were obtained with atenolol (5 X 10(-6) M), a beta-receptor antagonist without membrane-stabilizing effects. In the presence of 10(-5) M dl-propranolol, MH did not increase nucleoside release above control. Nucleoside release was similarly blocked during MH in the presence of 5 X 10(-6) M d-propranolol, which does not have the beta-blocking properties of the l-isomer.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6147099&dopt=Abstract
Kardiologiia. 1991 Aug;31(8):59-61.
[Prolonged cardioselective blockade of beta-1 adrenoreceptors in combination with increased diuresis as a method of choice in the treatment of hypertension]
[Article in Russian]
Ivashkin VT, Grigor'ev IuV, Sinopal'nikov AI, Korneev NV, Levitskii DN, KazakovaIG, Virs EA.
The clinical effects of Tenoric, a long-acting combined drug (atenolol and chlorthalidone in a tablet), were studied in 31 patients with Stages I and II hypertensive disease, by using echocardiography, daily automatic blood pressure monitoring, bicycle ergometry, measurements of plasma renin and aldosterone. The drug was found to be highly clinically effective in labile and sustained hypertension. When given once or twice a day, it makes it possible to reliably monitor blood pressure, improve hemodynamic parameters, as reflected by lower cardiac output and decreased peripheral vascular resistance, reduce the estimated mass of the left myocardium, alleviate a pressor response to exercise and enhance its tolerance, lower plasma renin levels. The side effects of the drug are minimal and include moderate bradycardia. Peripheral vasospasm and systemic weakness were observed in single cases. There were no atherogenic changes in lipid spectrum and disturbed glucose and uric acid metabolism during the drug therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1795477&dopt=Abstract
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