Drugs online research references
Acta Neurol Scand. 1982 Nov;66(5):547-54.
Atenolol vs. propranolol in essential tremor. A controlled, quantitative study.
Larsen TA, Teravainen H, Calne DB.
The beta-1 selective, hydrophilic adrenoceptor blocking drug atenolol (100 mg daily) was compared to the non-selective, lipid-soluble beta-blocker propranolol (240 mg daily), and to placebo, in a double-blind cross-over study in 24 patients with essential tremor. Atenolol and propranolol caused a similar decrease in heart rate. Both beta-blockers also suppressed the tremor intensity; there was no significant difference between them, but both were significantly better than placebo. These drugs did not affect tremor frequency. Twelve of the patients preferred propranolol subjectively, one preferred atenolol and none preferred placebo. No marked side-effects were observed. It was concluded that atenolol and other cardio-selective blockers offer an alternative for patients unable to tolerate the non-selective drugs. The site of action and receptor sub-type involved have still to be determined.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7148397&dopt=Abstract
Am J Hosp Pharm. 1994 Feb 15;51(4):508-11.
Stability of atenolol in an extemporaneously compounded oral liquid.
Garner SS, Wiest DB, Reynolds ER Jr.
College of Pharmacy, Medical University of South Carolina, Charleston 29425.
The stability of atenolol in an oral liquid stored for 40 days under various conditions was studied. A liquid preparation of atenolol 2 mg/mL was prepared by triturating 50-mg atenolol tablets with a commercially available oral diluent. Twelve 30-mL portions in vials were prepared. Three vials were refrigerated (5 degrees C) and shaken immediately before analysis, three were stored at room temperature (25 degrees C) and shaken, three were refrigerated and not shaken, and three were stored at room temperature and not shaken. One sample from each vial was assayed in duplicate on days 0, 15, 30, and 40 by stability-indicating high-performance liquid chromatography. The concentration of atenolol remained above 90% of the original concentration in each vial under each of the four sets of conditions. Microbial growth occurred in a few cultured samples, and pH changed minimally. Atenolol 2 mg/mL in an oral liquid was stable for up to 40 days when stored at 5 or 25 degrees C and shaken or at 5 or 25 degrees C and not shaken.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8017418&dopt=Abstract
Cardiologia. 1990 Sep;35(9):741-6.
[HR/QT ratio during ergometric test: influence of ischemia and beta blocking therapy]
[Article in Italian]
Ferraro S, Santomauro M, Maddalena G, D'Agosto V, Romano M, Fazio S, Chiariello M.
Cattedra di Cardiologia, II Facolta di Medicina e Chirurgia, Universita degli Studi, Napoli.
The aim of this study was to analyze the HR/QT relation during exercise in a group of patients with effort angina (Group B) in comparison with the same relation obtained in a group of normal subjects (Group A) comparable for age and sex. The regression analysis was carried out separately during effort in upright position and during rest in clinostatic position to avoid influences on QT by the patient's posture. During effort in patients of the Group B the regression shows a lower value of the slope and of the intercept (p less than 0.001) than those obtained in the subjects of the Group A. A similar behaviour is shown also from the regressions obtained during rest in the same groups. Thus at the highest HRs we observed a longer QT in the Group B. Moreover QT of ischemic patients in the presence of ECG signs of ischemia (ST less than or equal to 1 mm) resulted significantly longer (p less than 0.01) either during effort and at rest, respect to that obtained in Group A at comparable HRs. The analysis of the regression HR/QT after administration of atenolol 100 mg per os in a subgroup of patients of Group B clearly shows a less prolonged QT at the highest HRs where ECG ischemia frequently appears. This fact is demonstrated by the presence of a higher slope (p less than 0.05) respect to that obtained in the same group without therapy. In conclusion, myocardial transient ischemia provokes a longer QT in patients with ischemic heart disease in comparison with normal subjects. Acute therapy with atenolol per os is able to condition the regression HR/QT showing a relative shortening of QT at the highest HRs respect to that carried out in the same patients in absence of therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1982620&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics