Drugs online research references
Eur J Clin Pharmacol. 1985;28(1):41-3.
Atenolol inhibits the elimination of disopyramide.
Bonde J, Bodtker S, Angelo HR, Svendsen TL, Kampmann JP.
The effect of atenolol on the total elimination of disopyramide and its main dealkylated metabolite was studied in 6 patients and 3 volunteers. During administration of 50 mg atenolol b.i.d. the clearance of disopyramide decreased significantly (p less than 0.02) from 1.90 +/- 0.71 (mean +/- SD) to 1.59 +/- 0.68 ml/kg/min, while its half-life, concentration of the metabolite, and the volume of distribution remained unchanged. The reduction in the clearance of disopyramide by atenolol might contribute to the alleged pharmacodynamic interaction between disopyramide and beta-blocking drugs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3987784&dopt=Abstract
teknil.lth.se
Three different capillary electrochromatographic methods for the enantiomer separation of beta-adrenergic antagonists (acebutolol, alprenolol, atenolol, metoprolol, pindolol, prenalterol, and propranolol) were applied using different cyclodextrins (beta-cyclodextrin, carboxymethyl-beta-cyclodextrin and dimethyl-beta-cyclodextrin) added to the electrolyte, a cross-linked protein-gel (cellobiohydrolase I) and a molecularly imprinted ((R)-enantiomer of propranolol) superporous polymer as chiral selectors. Through use of these different separation strategies, all the beta-adrenergic antagonists studied could be resolved into their enantiomers, although the three methods were carried out without extensive optimization. The protein and molecularly imprinted phases gave the highest selectivities whereas employing cyclodextrins resulted in the highest separation efficiency. Proteins and cyclodextrins are primarily natural products, albeit the cyclodextrins can be derivatized. In contrast, the molecularly imprinted chiral stationary phase can be highly customized when produced.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9221873&dopt=Abstract
J Chromatogr. 1990 Nov 2;519(2):285-98.
Separation of the enantiomers of beta-receptor blocking agents and other cationic drugs using a CHIRAL-AGP column. Binding properties and characterization of immobilized alpha 1-acid glycoprotein.
Enquist M, Hermansson J.
Apoteksbolaget AB, Department of Biomedicine, Stockholm, Sweden.
The effect of the immobilization procedure on the conformation of alpha 1-acid glycoprotein (AGP) was investigated by recording the fluorescence spectra of native and immobilized AGP. A 20-nm red shift was obtained for the immobilized form of AGP compared with the emission maximum of 338 nm obtained for native AGP. This demonstrates that the tryptophan residues are exposed on the protein surface after immobilization, indicating that the immobilized form of AGP has a more unfolded structure than the native AGP. The effect of N,N-dimethyloctylamine on the enantioselectivity for some fentiazine derivatives, observed with immobilized AGP, was equal to that obtained with AGP as a chiral complexing agent in the mobile phase. This demonstrates that even though the immobilization procedure affects the conformation of the protein there still exist large similarities between native and immobilized AGP concerning chiral recognition. The adsorption isotherm of (-)-terodiline was studied by use of the breakthrough technique. The adsorption isotherm indicates that (-)-terodiline is adsorbed to one site with high affinity and at least one more site with lower affinity. It was also observed that the enantiomers of amines, acids and non-protolytic compounds compete with the cationic compound, (-)-terodiline, for binding to the same sites. The beta-receptor blocking agents atenolol, metoprolol, pindolol, alprenolol, oxprenolol and propranolol were resolved on a CHIRAL-AGP column. The retention and enantioselectivity are highly influenced by the structure of the solute and the nature of the uncharged mobile phase additives. Separation factors of 1.2-1.8 were obtained for the beta-blockers under the studied conditions.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1979791&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics