Drugs online research references
J Clin Pharmacol. 1990 Feb;30(2 Suppl):S124-31.
Effect of short-term beta blockade on serum lipid levels and on the interaction of LDL with human arterial proteoglycans.
Linden T, Camejo G, Wiklund O, Warnold I, Olofsson SO, Bondjers G.
Wallenberg Laboratory for Cardiovascular Research, Department of Medicine I, Gothenburg University, Sahlgrenska Hospital, Sweden.
In view of conflicting evidence suggesting that beta-blockers have an anti-atherogenic effect as well as induce a potentially atherogenic lipoprotein profile, the effects of a short term beta-blockade on serum lipoproteins were studied in 39 healthy volunteers. Because the interaction of LDL with arterial proteoglycans appears to play a role in lipoprotein accumulation during atherogenesis, the effects of metoprolol and atenolol on low density lipoprotein interaction with human aortic proteoglycans were included in the study. We could confirm that the beta-blockers caused a decrease in HDL cholesterol and an increase in triglycerides, both potentially undesirable effects. In addition, however they induced a significant decrease in the in vitro LDL affinity for arterial proteoglycans. Since there appears to be a strong association between LDL reactivity with proteoglycans and risk for myocardial infarction, this effect of the beta-blockers may be an anti-atherogenic effect which overrides other effects on the lipoprotein pattern.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2107215&dopt=Abstract
Med Sci Sports Exerc. 1987 Aug;19(4):382-8.
Effect of beta 1-receptor blockade on coronary resistance in partially trained dogs.
Liang IY, Stone HL, Gwirtz PA.
Department of Physiology, Texas College of Osteopathic Medicine, Fort Worth 76107.
Selective beta 1-receptor blockade with atenolol (1 mg X kg-1, i.v.) was used to determine the effect of partial exercise training on diastolic coronary resistance (DCR) during sub-maximal exercise. Seven conscious dogs were studied in the untrained (UT) and partially trained (PT) conditions. The conditioning regime consisted of treadmill running 5 d X wk-1 for 4 to 5 wk. Left circumflex coronary flow, aortic pressure, and heart rate were measured, and DCR and myocardial oxygen consumption were calculated. During sub-maximal exercise, DCR in the UT dogs decreased from a resting value of 4.08 +/- 0.18 mm Hg X ml-1 X min-1 to 1.91 +/- 0.17 mm Hg X ml-1 X min-1 at a workload of 6.4 kph (speed)/16% (grade). During exercise, DCR was significantly greater in UT than in PT dogs. Atenolol significantly increased DCR at all levels of sub-maximal workload in both UT and PT dogs. However, the percent increase in DCR with atenolol was significantly greater in the PT dogs compared to UT dogs. These findings suggest that daily exercise for 4 to 5 wk may decrease beta 2-receptor activity of the coronary vasculature during sub-maximal exercise.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2821340&dopt=Abstract
Angiology. 1986 Mar;37(3 Pt 2):218-20.
Future/novel uses of beta blockers in clinical therapeutics.
Maclean D.
Beta-blocker usage in the United Kingdom centers around propranolol and oxprenolol as noncardioselective drugs, atenolol and metoprolol as cardioselective agents, and pindolol or oxprenolol when partial agonist activity is desired. Any meaningful comparison of a novel beta blocker against the established drugs must be a variable-dose trial, for the optimum dose of any beta blocker that can be tolerated varies widely. Effective beta blockade is considered to have been achieved when the standing heart rate has been lowered to about 55 beats/minute.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2871780&dopt=Abstract
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