Drugs online research references
Am J Obstet Gynecol. 1990 Jul;163(1 Pt 1):37-40.
Beta-adrenergic receptor blockade in the management of pregnant women with mitral stenosis.
al Kasab SM, Sabag T, al Zaibag M, Awaad M, al Bitar I, Halim MA, Abdullah MA, Shahed M, Rajendran V, Sawyer W.
Riyadh Cardiac Centre, Armed Forces Hospital, Saudia Arabia.
Twenty-five pregnant women with symptomatic mitral valve stenosis (mean valve area, 1.1 +/- 0.25 cm2) were managed by initiation or modification of beta-adrenergic receptor blockade with the use of either propranolol or atenolol. Significant improvement of symptoms occurred in 23 patients (92%) (p less than 0.01); the mean maternal heart rate was reduced significantly from 86 +/- 4 to 78 +/- 5 beats/min (p less than 0.0001). The overall fetal heart rate ranged between 130 to 150 beats/min during treatment. Only two patients required urgent closed mitral valvotomy, after pulmonary edema developed as a result of poor compliance to beta-blockade. All patients were safely delivered of infants at term. Fetal heart rates ranged between 120 to 140 beats/min at delivery. There was no maternal or fetal death. Pregnant woman with symptomatic mitral valve stenosis can be safely managed with beta-blockade, giving significant reduction in the incidence of pulmonary edema with no unwanted neonatal side effect.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1973871&dopt=Abstract
Clin Pharmacol Ther. 1982 May;31(5):555-8.
Beta-adrenergic-receptor blockers and antinuclear antibodies in hypertension.
Booth RJ, Wilson JD, Bullock JY.
It has recently been reported that the Beta-adrenergic receptor-blocker acebutolol accelerates the development of antinuclear antibodies (ANAs) in hypertensive patients. We examined data from over 1500 hypertensive patients to determine whether this effect is associated with other beta blockers. Groups of patients treated with acebutolol, atenolol, labetalol, and pindolol all displayed increased development of ANAs relative to patients on other medication. When patients taking methyldopa (a drug associated with a high ANA incidence) were excluded from the analysis, only acebutolol retained an association (P less than 0.001) with ANA production. Sequential studies to assess the development of ANAs in patients during the course of beta-blocker treatment revealed a similar pattern. With methyldopa patients excluded, the fraction of patients developing ANAs was less then 10% for all but atenolol (10.9%), labetalol (13.8%), and acebutolol (33%). Thus, although some of the beta blockers may be associated with an increase in ANA incidence, the dramatic effects of acebutolol do not appear to be a group property.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6122525&dopt=Abstract
Biol Pharm Bull. 1996 Jul;19(7):932-5.
Effects of chronic administration of bopindolol on the binding characteristics of cardiac alpha 1H-, alpha 1L-, beta 1- and beta 2-adrenoceptor subtypes in cardiac muscles of spontaneously hypertensive rats (SHR).
Hosohata Y, Sasaki K, Maruyama K, Ohnuki T, Hattori K, Suzuki J, Watanabe K, Nagatomo T.
Department of Pharmacology, Niigata College of Pharmacy, Japan.
The effects of the chronic administration of bopindolol on the binding characteristics of [3H]CGP12177 and [3H]prazosin to cardiac alpha 1H-, alpha 1L-, beta 1- and beta 2-adrenoceptor subtypes of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were compared with those of two other beta-blockers, atenolol and propranolol. Bopindolol (1 and 3 mg/kg/d), atenolol (50 mg/kg/d) and propranolol (60 mg/kg/d) were given to 10-week-old SHR for 12 weeks. The changes in Kd and Bmax values of the myocardium of SHR treated without and those drugs were assessed by Scatchard analysis, and the ratio and Bmax values of the beta 1- and beta 2-adrenoceptor subtypes were also calculated from displacemental curves using ICI 118,551. The systolic blood pressure in SHR was dose-dependently lowered by the administration of bopindolol, and was also lowered by the administration of atenolol and propranolol. The Bmax values of beta 1- and beta 2-adrenoceptors were lowered by the administration of bopindolol (1 and 3 mg/kg/d) without any changes in the Kd values or the ratio of beta 1- and beta 2-adrenoceptors. Propranolol lowered 3-fold the affinity to the beta-adrenoceptor. On the other hand, the Kd and Bmax values of alpha 1H- and alpha 1L-adrenoceptor subtypes (high and low affinity binding sites for [3H]prazosin) were not changed by these drugs. These findings suggest that bopindolol had a beneficial effect on beta-adrenoceptors in the membranes of cardiac muscles of SHR, implying that these effects may contribute to lowering hypertension.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8839963&dopt=Abstract
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