Drugs online research references
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Helicobacter pylori infection is frequent in children. Its incidence in Europe, around 6% in children aged 6-16 years, varies with the socio-economic level and nutritional status. It may reach 46% in Africa and up to 75% in some institutions. Clinical manifestations debated. Vomiting, dyspepsia and acute pain related to ulcer disease may undisputedly be linked to H. pylori, whereas its role in chronic abdominal has yielded contradictory reports. Direct isolation of the bacterium is classically done through perendoscopic antral biopsies followed by culture and histology. Non-invasive diagnosis methods get a wider use in children. Serodiagnosis is reproducible and easy only in older children. The 13C-urea breath test is sensitive and specific, and seems perfectly suitable in pediatrics. The H. pylori stool antigen test for the detection of infection seems promising but not yet of current clinical use. Triple therapy using amoxicillin-clarithromycin (or metronidazole or tinidazole) and anti-secretory agents is recognised as the most efficient association.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11019636&dopt=Abstract
Emerg Infect Dis. 2001 May-Jun;7(3):428-33.
Melioidosis: an emerging infection in Taiwan?
Hsueh PR, Teng LJ, Lee LN, Yu CJ, Yang PC, Ho SW, Luh KT.
National Taiwan University Hospital, Taipei, Taiwan.
From January 1982 to May 2000, 17 infections caused by Burkholderia pseudomallei were diagnosed in 15 patients in Taiwan; almost all the infections were diagnosed from 1994 to May 2000. Of the 15 patients, 9 (60%) had underlying diseases, and 10 (67%) had bacteremic pneumonia. Thirteen (76%) episodes of infection were considered indigenous. Four patients died of melioidosis. Seventeen B. pseudomallei isolates, recovered from eight patients from November 1996 to May 2000, were analyzed to determine their in vitro susceptibilities to 14 antimicrobial agents, cellular fatty acid and biochemical reaction profiles, and randomly amplified polymorphic DNA patterns. Eight strains (highly related isolates) were identified. All isolates were arabinose non-assimilators and were susceptible to amoxicillin-clavulanate, piperacillin-tazobactam, imipenem, and meropenem. No spread of the strain was documented.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11384520&dopt=Abstract
Arch Pediatr. 2000 Jun;7 Suppl 3:551s-558s.
[Pathology of Haemophilus infections: current situation in pediatrics]
[Article in French]
Kurkdjian PM, Bourrillon A, Holvoet-Vermau L, Bingen E.
Service de pediatrie generale, hopital Robert-Debre, Paris, France.
Haemophilus influenzae is the main pathogen in community-acquired infections in children. Prior to the introduction of H. influenzae type b immunization (Hib), capsular type b H. influenzae was the most invasive type of H. influenzae, and was the major cause of meningitis in children in France and many developing countries. The introduction of a Hib vaccine program results in rapid and dramatic decline in the incidence of Hib infections in children. The resistance rate to beta-lactam antibiotics is slowly increasing with beta-lactamase production. Third generation cephalosporins are used for the treatment of invasive infection (meningitis etc.). The empiric treatment of otitis and respiratory tract infections in children is the combination of clavulanic acid and amoxicillin or third generation cephalosporins.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10941479&dopt=Abstract
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