Drugs online research references
Arzneimittelforschung. 1978;28(8):1301.
[Quantitative determination of tricyclic antidepressant drugs by high-pressure liquid chromatography (author's transl)]
[Article in German]
Kuss BJ, Nathmann M.
With regard to the increasing importance of determining plasma levels of antidepressant drugs a procedure has been worked out which makes it possible to analyze these substances in a simple and sensitive way. 5 ng )ca. 20 pmol) amitriptyline, nortriptyline, imipramine, desmethylimipramine, chlorimipramine, desmethylchlorimipramine, and protriptyline can be detected with a high-pressure liquid chromatograph and a UV-monitor without prior derivatisation. The extraction is made from 1 ml serum. Because of their retention time the substances can be identified. This fact allows simultaneous analyzation of all tricyclic antidepressants.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=582392&dopt=Abstract
Neurol Neurochir Psychiatr Pol. 1965 Mar-Apr;15(2):289-91.
[The estimate of efficiency of amitriptyline activity in pscyhoses with depressive reactions]
[Article in Polish]
Cwynar S, Nagurska H.
PMID: 5837690
Acta Psychiatr Belg. 1979 Jan-Feb;79(1):96-108.
[Study of intravenous amitriptyline in acute depressions (author's transl)]
[Article in French]
Brasseur R.
The author has performed an open study of 27 patients with an acute depressive state, hospitalized and treated with slow intravenous perfusions of amitriptyline. Similar perfusions of chlorimipramine act certainly more rapidly on depression, but conversion to oral dose raises some problems regarding active dosis. Intravenous amitriptyline reduces latency, is more sedative and without major intolerance, such as hemodynamic. Conversion to oral diffused forms (Redomex diffucaps) consolidates the results obtained by parenteral administration, and the antianxiety component permits the use of this drug in monotherapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=495165&dopt=Abstract
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