Drugs online research references
Therapeutique. 1971 Dec;47(10):861-6.
[Study in psychodermatology of 2 associations with mixed action, antidepressive and tranquilizing (amitriptyline + perphenazine)]
[Article in French]
Privat Y, Bonniol JP.
PMID: 5145549
Psychopharmacologia. 1969;14(3):184-92.
The effect of amitriptyline on pulmonary ventilation and the mechanics of breathing.
Avni J, Bruderman I.
PMID: 5351859
Eur J Clin Pharmacol. 1977 Nov 14;12(3):187-90.
Comparative bioavailability of a sustained release preparation of amitriptyline and conventional tablets.
Jorgensen A.
A sustained release preparation of amitriptyline has been compared with conventional tablets in eight healthy human volunteers. The tablet produced a distinct peak in serum concentration shortly after administration, whereas the sustained release preparation caused a slow rise to a plateau. The maximum serum concentration and the time of its occurrence differed significantly between the two preparations. The differences between the serum concentration curves of the two preparations can be explained on the basis of a two compartment model of amitriptyline pharmacokinetics and from a difference in the absorption rate. The similar clinical effect obtained with a lower daily dose of the sustained release preparation than of the tablet cannot be accounted for in terms of pharmacokinetics. It is possible that a single evening dose of sustained release amitriptyline gives a more appropriate serum concentration profile of amitriptyline and its active metabolite nortriptyline than a conventional tablet taken three times a day.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=579343&dopt=Abstract
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