Drugs online research references
Cancer Drug Deliv. 1986 Fall;3(4):219-22.
The effect of amitriptyline on the central nervous system penetration of methotrexate.
Heideman RL, Balis FM, Zimm S, Lester CM, Poplack DG.
The reported ability of amitriptyline to enhance the penetration of diffusion limited substances across the blood brain barrier was investigated. The CSF:plasma ratio of methotrexate in primates was not significantly altered by amitriptyline pretreatment. Nor was methotrexate plasma clearance altered.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3567842&dopt=Abstract
Ther Drug Monit. 1987;9(1):6-10.
Steady-state concentrations of amitriptyline and its metabolite nortriptyline in Saudi patients.
el-Yazigi A, Chaleby K.
The serum concentrations of amitriptyline (AMI) and its metabolite nortriptyline (NT) were determined in 54 Saudi patients treated for long durations with a daily oral dose (0.111 to 4.167 mg/kg) of AMI. Ten of these patients were concomitantly treated with neuroleptic drugs. The mean (SEM) of the dose-normalized steady-state serum concentration (Css) of AMI in patients who received AMI alone (Group I) was [46.1 (6.5) ng X ml-1/mg X kg-1], with mean NT/AMI Css ratio of 0.962 (0.122). A significantly higher mean of Css of AMI [82.3 (18.8 ng X ml-1/mg X kg-1] was acquired for patients who concomitantly received AMI and neuroleptic drugs (Group II). However, the difference in the mean NT/AMI Css ratio between Group I and Group II [0.929 (0.197)] was not significant. Also, the results of this study indicate that Css of AMI and the NT/AMI Css ratio in Saudi patients treated for depression with AMI alone are not significantly different from those reported for subjects from Western populations.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3576661&dopt=Abstract
Clin Chim Acta. 1987 Jun 15;165(2-3):177-87.
Therapeutic drug monitoring of amitriptyline: impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women.
Edelbroek PM, Zitman FG, Knoppert-van der Klein EA, van Putten PM, de Wolff FA.
Toxicology Laboratory, University Hospital of Leiden, The Netherlands.
Concentrations of amitriptyline (AT), nortriptyline (NT) and E-10-hydroxynortriptyline (E-10-OH-NT) were measured in 18 women with bulimia receiving 100 mg AT/day for at least 6 wk. After onset of treatment between days 36 and 57 there is a decrease in AT and an increase in E-10-OH-NT concentrations, probably due to an autoinductive effect on hydroxylation. The estimated mean (+/- SD; range; n) elimination half-life time of AT was 14.0 (+/- 7.8 h; 7.5-38.5 h; 14). On day 36, AT concentrations in females using oral contraceptives (OC) were higher than in non-users of OC, which indicates inhibition of AT metabolism by OC. In all smokers the E-10-OH-NT concentrations on day 36 were lower than in non-smokers. Our findings suggest induction of N-demethylation and glucuronidation by smoke components.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3652444&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Tramadol ||
Antibiotics and prescription medications online literature ||
Antibiotics