Drugs online research references
Agents Actions. 1986 Apr;18(1-2):89-91.
Non-differential inhibition of histamine and serotonin release from mast cells by amitriptyline.
Berlin G, Enerback L.
A differential amine release from mast cells induced by an inhibitory effect of the antidepressant drug amitriptyline on the release of histamine but not on that of serotonin has recently been reported. In view of the potential biological importance of a differential release of mast cell amines we have studied the effect of amitriptyline on the dynamics of the secretory process using a combination of vital berberine staining (demonstrating intracellular granules that have released amines) and measurement of histamine, serotonin (5-HT), and heparin release. The results show a non-differential inhibition of the release of histamine and 5-HT by amitriptyline. The basic pattern of the secretory process, studied in terms of granule extrusion and amine release from intracellular granules, was unaffected by the drug.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2425600&dopt=Abstract
Psychopharmacology (Berl). 1989;97(2):277-9.
A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety.
Bodnoff SR, Suranyi-Cadotte B, Quirion R, Meaney MJ.
Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
We examined the anxiolytic effects of a variety of anti-depressant drugs, administered either acutely or chronically, in an animal model of anxiety involving novelty-suppressed feeding in food-deprived rats. Following a single injection of desipramine (10 mg/kg) amitriptyline (10 mg/kg), mianserin (10 mg/kg), fluoxetine (10 mg/kg), buspirone (4 mg/kg), gepirone (4 mg/kg) or nomifensine (10 mg/kg), there was no decrease in the latency to begin eating in the novel environment such as occurred with diazepam (2 mg/kg). In fact, an increased latency was observed for desipramine, amitriptyline, fluoxetine, and nomifensine. In contrast, chronic (21 days) treatment with each of the above-mentioned drugs, except nomifensine, significantly reduced the latency to begin eating relative to vehicle controls. These findings suggest that a variety of tricyclic and novel anti-depressant drugs acquire anxiolytic properties following chronic administration.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2567028&dopt=Abstract
Neuropsychobiology. 1989;20(3):132-5.
Acute amitriptyline effects on parasympathetic-evoked rat saliva.
Yu JH, Chen YY, Suarez K.
Georgetown University School of Dentistry, Washington, D.C.
The present study was undertaken to investigate the acute effects of amitriptyline on salivary secretion evoked by electrical stimulation of the parasympathetic innervations of rat salivary glands. Single intravenous injections of amitriptyline (0.1-1 mg/kg) caused a dose-related decrease in flow and Na concentration of saliva from both parotid and submandibular glands. However, the only effect on K concentration was a slight increase when the salivary flow was almost completely inhibited. Amitriptyline increased the Ca concentration of nerve-evoked submandibular saliva, but had no effect on the Ca concentration of similarly evoked parotid saliva. However, amitriptyline (0.5 and 1 mg/kg) increased the protein concentration of both kinds of saliva. Amylase activity of parotid saliva was also moderately increased by amitriptyline. These effects were similar to those observed with atropine, a known cholinergic receptor antagonist. These results suggest that amitriptyline, like atropine, reduces parasympathetic-evoked salivary secretion by blocking cholinergic receptors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2761682&dopt=Abstract
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