Drugs online research references
J Pharmacol Exp Ther. 1982 Nov;223(2):388-95.
Role of the central adrenergic system in mediating amitriptyline-induced alteration in the mammalian blood-brain barrier in vivo.
Preskorn SH, Hartman BK, Irwin GH, Hughes CW.
All tricyclic antidepressants increase the degree of equilibration of [3H]water across the cerebral capillary (Ew) as measured by a dual-label radioactive tracer technique. By using amitriptyline (AMI) as a prototype, a series of studies was conducted to determine the mechanism for this drug effect. The AMI-induced increase in Ew was blocked by 6-hydroxydopamine ablation of central aminergic neurons and by pretreatment with phenoxybenzamine, an alpha adrenergic antagonist. Pretreatment with propranolol, a beta adrenergic antagonist, did not block the AMI-induced increase. Central serotonergic ablation by p-chloroamphetamine had no effect on the AMI-induced increase. Treatment with atropine and hydroxyzine separately also did not alter Ew. Based on these results, the AMI-induced increase in Ew appears to be mediated by the effect of the drug on central adrenergic neurons. The serotonergic, anticholinergic and antihistaminergic actions of AMI, by themselves, do not appear to play a role in this phenomenon. The results are compatible with the concept that the central adrenergic system functions, in part, to regulate the cerebromicrocirculation.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6813452&dopt=Abstract
J Affect Disord. 1980 Jun;2(2):89-94.
A re-examination of the clinical effects of imipramine and amitriptyline in depressive illness.
Beaini AY, Hindmarch I, Snaith RP.
A double-blind trial of amitriptyline and imipramine was conducted in patients suffering from depressive illness. The results failed to confirm the prevalent belief that amitriptyline has a greater sedative effect and superior anxiolytic properties than imipramine. The therapeutic effect of these drugs was not shown to be related to their sedative properties and with regard to anxiety the reverse appeared to be true.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6448887&dopt=Abstract
J Clin Psychiatry. 1982 Nov;43(11):457-60.
Amitriptyline overdose: clinical effects on tricyclic antidepressant plasma levels.
Rudorfer MV, Robins E.
Tricyclic antidepressant (TCA) plasma levels after amitriptyline overdose were reviewed in a retrospective study. Amount of drug taken correlated with total TCA levels. Plasma concentrations were higher in blacks than whites, but no association could be found between TCA levels and age or sex of patients. History of routine use of amitriptyline at the time of overdose did not predict TCA levels, but the one fatality could be shown on the basis of previous steady-state levels to be a slow metabolizer. Serious overdoses as documented by high plasma TCA levels were seen in all major diagnostic groups.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7174623&dopt=Abstract
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