Drugs online research references
Gen Pharmacol. 1986;17(5):607-10.
Effects of antidepressants on receptor-activated and Ca2+-activated contractions of rabbit isolated aorta.
Auguet M, Clostre F, DeFeudis FV.
Helically-cut strips of rabbit aorta were used to examine the inhibitory effects of some antidepressants on the contractile responses produced by norepinephrine (NE), serotonin (5-HT) or K+. The order of potency of antidepressants in antagonizing 5-HT-induced responses was: mianserin greater than amitriptyline greater than imipramine (IMI) greater than desipramine greater than or equal to nomifensine. With NE as agonist, the order of potency was: amitriptyline greater than mianserin greater than IMI greater than desipramine greater than or equal to nomifensine. Viloxazine (10(-5) M) was ineffective on 5-HT- or NE-induced contractions. For K+-induced contraction (which is mediated by Ca2+ entry into smooth muscle cells) tricyclic antidepressants were about equipotent with mianserin; nomifensine and viloxazine were relatively ineffective. These results indicate that certain antidepressants have multiple effects on arterial smooth muscle. Such effects could underlie not only the side-effects, but also the therapeutic actions of these agents.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3023174&dopt=Abstract
Forensic Sci Int. 1987 May-Jun;34(1-2):73-83.
Detection of drug residues on the hands of subjects by surface sampling and ion mobility spectrometry.
Lawrence AH.
This paper deals with the detection of drug residues on the hands of human subjects. The results demonstrate that detectable amounts of particulate matter are transferred to the hands by brief contact with drug tablets. A sampling and analysis method has been developed, and is based on the aspirating and trapping of drug microparticles on a filter plug, to be followed by thermal desorption directly into an ion mobility spectrometer. The technique is suited for initial field screening in clinical and forensic applications. The major drugs detected were diazepam, amitriptyline, codeine, acetaminophen, nitroglycerin, and delta 9-tetrahydrocannabinol (delta 9-THC).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3110037&dopt=Abstract
Ther Drug Monit. 1987;9(1):120-2.
No interaction of diazepam on amitriptyline disposition in depressed patients.
Otani K, Nordin C, Bertilsson L.
PMID: 3576658
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Tramadol ||
Antibiotics and prescription medications online literature ||
Antibiotics