Drugs online research references
J Pharm Pharmacol. 1962 Aug;14:509-14.
Effect of imipramine, amitriptyline and their monomethyl derivatives on reserpine activity.
GARATTINI S, GIACHETTI A, JORI A, PIERI L, VALZELLI L.
PMID: 13896732 [PubMed - OLDMEDLINE for Pre1966]
J Chromatogr. 1976 Sep 15;124(2):401-4.
Simultaneous determination of therapeutic levels of amitriptyline and nortriptyline in plasma by gas-liquid chromatography.
Corona GL, Bonferoni B.
PMID: 965471
Methods Find Exp Clin Pharmacol. 1989 Oct;11(10):635-9.
Effects of antidepressants on alcohol-induced gastric mucosal injury in rats.
Fernandez de la Gandara F, Casas Carnicero J, Velasco Martin A.
Dept. of Surgery, Faculty of Medicine, Valladolid, Spain.
The purpose of the present report is to study the effects of antidepressants such as trimipramine, amitriptyline, maprotiline and mianserin on severe gastric mucosal lesions produced by ethanol in comparison with cimetidine (H2-antihistamine) and dexchlorepheniramine (H2-antihistamine). The percentage of macroscopic mucosal lesions caused by alcohol affects 15% of the mucosal area. But pretreated with cimetidine the affected area was 9.18%, with dexchlorepheniramine 5.01%, with trimipramine 14.46%, with amitripytline 7.94%, with maprotiline 3.8%, and with mianserin 4.07%. Microscopic evaluation reveals that ethanol produces destruction of glandular cells and injures medial and basal layers. All drugs used previously to ethanol produce a decrease of microscopical lesions. A direct relation was found between micro and macroscopical lesions in rats treated with maprotiline, mianserin and dexchlorepheniramine.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2586196&dopt=Abstract
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