Drugs online research references
J Pharm Sci. 1978 Jan;67(1):60-2.
Quantitative determination of amitriptyline in blood.
Kaul PN, Whitfield LR, Clark ML.
An assay was developed and standardized for amitriptyline and its hydroxylated tertiary amine metabolites in blood and other biological tissues. This method is capable of determining 5--15 ng of these compounds/ml and is based on reacting the drug as base with 9-bromomethylacridine to form a quaternary product which, on photolysis, yields fluorescence in a stoichiometric fashion. The precision of the method is usually around +/-5%.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=619116&dopt=Abstract
J Affect Disord. 1984 Oct;7(2):133-8.
Weight gain. A side-effect of tricyclic antidepressants.
Berken GH, Weinstein DO, Stern WC.
Body weight and appetite were evaluated in 40 depressed outpatients from a private psychiatric practice who were receiving low-modest doses of tricyclic antidepressants. Amitriptyline (maximum of 150 mg/day), nortriptyline (maximum of 50 mg/day), and imipramine (maximum of 80 mg/day) were given for an average of 6 months of treatment. There was a mean weight increase of 1.3-2.9 lbs/month, which led to an average total weight gain of 3-16 lbs, depending on drug, dose and duration. These weight increases were linear over time and were accompanied by marked increases in the preference for sweets. Ultimately, excessive weight gain was the most common cause of discontinuation of treatment, occurring in one-half of the patients. Significant weight loss occurred upon discontinuation of drug. These findings show that chronic administration of low-modest doses of tricyclic antidepressants frequently cause considerable weight gain and can significantly interfere with the ability to provide long-term maintenance therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6238068&dopt=Abstract
Br J Pharmacol. 1978 Jun;63(2):370P-371P.
A radioimmunoassay for amitriptyline and nortriptyline [proceedings]
Braithwaite RA, Montgomery S, Robinson JD.
PMID: 667450
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