Drugs online research references
Life Sci. 1990;47(18):1683-91.
Effect of prolonged 5-hydroxytryptamine uptake inhibition by paroxetine on cortical beta 1 and beta 2-adrenoceptors in rat brain.
Nelson DR, Palmer KJ, Johnson AM.
SmithKline Beecham Pharmaceuticals, Research and Development, Harlow, Essex, UK.
The effects of prolonged (21 day) oral administration of the antidepressants paroxetine (0.9 to 8.9 mg/kg/day) and amitriptyline (2.7 to 27 mg/kg/day), on rat brain cortical beta 1- and beta 2-adrenoceptor numbers and affinities were investigated using [3H]-CGP 12177. Although amitriptyline, 27 mg/kg, caused a significant (p less than 0.05) 20% reduction in the number of beta 1-adrenoceptors, paroxetine, at doses up to 8.9 mg/kg p.o., did not influence binding of [3H]-CGP 12177 to cortical beta 1- or beta 2-adrenoceptors. This study with paroxetine provides further evidence that the down-regulation of central beta 1-adrenoceptors in rat brain after repeated administration is not a property of all antidepressant drugs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1979137&dopt=Abstract
Therapie. 1966 May-Jun;21(3):675-84.
[Action of imipramine, amitriptyline and their monodemethylated derivatives on the after-discharges induced by the excitation of certain rhinencephalic structures in rabbits]
[Article in French]
Schmitt H, Schmitt H.
PMID: 5942132
Naunyn Schmiedebergs Arch Pharmacol. 1988 Feb;337(2):220-4.
Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.
Eap CB, Cuendet C, Baumann P.
Clinique Psychiatrique Universitaire de Lausanne, Hopital de Cery, Prilly, Switzerland.
The S- and F-forms of alpha-1 acid glycoprotein (AAG) variants have been isolated by isoelectric focusing with immobilines from commercially available AAG. In equilibrium dialysis experiments using a multicompartmental system, a higher affinity for various basic drugs has been found with S- in comparison with F-AAG: Amitriptyline, nortriptyline, imipramine, desipramine, trimipramine, methadone, thioridazine, clomipramine, desmethylclomipramine, and maprotiline. The selectivity (binding to S- vs. F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3368020&dopt=Abstract
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