Drugs online research references
Therapie. 1967 Nov-Dec;22(6):1331-5.
[Action of imipramine, amitriptyline and cocaine on auto-stimulation in the rat]
[Article in French]
Benesova O.
PMID: 5590798
Psychopharmacology (Berl). 1990;101(2):255-61.
Pharmacological validation of a novel animal model of anticipatory anxiety in mice.
Lecci A, Borsini F, Volterra G, Meli A.
A. Menarini Pharmaceuticals, Pharmacological Research Department, Firenze, Italy.
The current study investigates the action of anxiolytics, antidepressants, neuroleptics, antipyretics, muscle relaxants, antihypertensives and naloxone in a novel animal model of anxiety, based on the evidence that mice removed last from their cage develop hyperthermia (stress-induced hyperthermia, SIH) when compared to those removed first. Alprazolam (0.15-0.6 mg/kg), chlordiazepoxide (25 mg/kg), estazolam (1 mg/kg), phenobarbital (20 mg/kg), ethanol (2 and 4 g/kg), buspirone (5 and 10 mg/kg) and prazosin (1 and 2 mg/kg), as well as repeatedly administered diazepam (5 mg/kg), inhibited SIH. In contrast, tofisopam (12.5-200 mg/kg), desipramine (15 and 30 mg/kg), amitriptyline (10 mg/kg), fluoxetine (10 and 20 mg/kg), tranylcypromine (5 and 10 mg/kg), chlorpromazine (1 and 2 mg/kg), clozapine (2 and 4 mg/kg), pimozide (0.5 and 1 mg/kg), l-sulpiride (15 and 30 mg/kg), l-propranolol (5 and 10 mg/kg), acetyl salicylic acid (200 and 400 mg/kg), indomethacin (2.5 and 5 mg/kg), verapamil (2.5 and 5 mg/kg), captopril (25 and 50 mg/kg), dantrolene (10 and 20 mg/kg), mephenesin (300 and 600 mg/kg), d-amphetamine (1 and 4 mg/kg) and naloxone (2.5 and 15 mg/kg) were inactive, as were 10 mg/kg imipramine, amitriptyline and fluoxetine injected every day for 21 days. Reserpine at high doses (1.25 and 2.5 mg/kg) but not at a lower dose (0.62 mg/kg) prevented SIH, but in this case animals showed a behavioural syndrome which could have interfered with the occurrence of the hyperthermia.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1971957&dopt=Abstract
Agents Actions. 1988 Apr;23(3-4):161-4.
Histamine releasing action of calcium ionophore 985-I.
Gushchin IS, Zebrev AI, Voitenko VG.
Laboratory of Cytology, Institute of Immunology, Moscow, USSR.
The polyether antibiotic 985-I induced histamine release from rat and mouse mast cells and human basophils. Histamine release induced by low concentrations (10-50 microM) of the ionophore was a selective (noncytotoxic) process. It was energy and Ca2+-dependent and was potentiated by glucose. In this respect the mode of action of 985-I was similar to that of the Ca2+-ionophore A23187. On the other hand some pharmacological agents (phencarol, verapamil and amitriptyline) inhibited histamine secretion induced by 985-I but not A23187-induced histamine release. These data point to some differences between the mechanisms of action of 985-I and A23187.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2455977&dopt=Abstract
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